Zhou Li, Zhang Hong-Xing, Liu Ling-Guang, Wan Wen-Jun
Department of Acupuncture and Moxibustion, Wuhan Chinese and Western Medicine Hospital, Wuhan, Hubei Province 430022, China.
Zhong Xi Yi Jie He Xue Bao. 2008 Jan;6(1):89-92.
To investigate the effect of electro-acupuncture (EA) at Fenglong (GV 16) on body weight, blood lipids, nitric oxide (NO) and endothelin (ET) in rats with hyperlipidemia (HLP).
Eighty Wistar rats were randomly divided into normal control group (fed normal diet), untreated group (fed a high-fat diet), EA-treated group (fed a high-fat diet plus EA therapy) and pravastatin-treated group (fed a high-fat diet plus pravastatin tablet). There were 20 rats in each group. The body weight and the blood content of total cholesterol (TC), triacylglycerol (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), NO the and ET of the rats in different groups were measured before experiment and after 30-day treatment. A modified method of cardiac puncture for blood sampling was used for blood collection.
Compared with the normal control group, the body weight and the levels of TC, TG, LDL-C and ET in the untreated group were significantly elevated (P<0.01, P<0.05), while the levels of HDL-C and NO were obviously decreased (P<0.05). The body weight and the levels of TC, TG, LDL-C demonstrated significant reduction in pravastatin-treated group and EA-treated group as compared with the untreated group (P<0.01), and the NO content in pravastatin-treated group and EA-treated group was higher than that in the untreated group (P<0.01). Compared with the untreated group, HDL-C level was elevated significantly in pravastatin-treated group, while HDL-C level in EA-treated group was not changed significantly, and there was significant difference in the HDL-C level between pravastatin-treated group and EA-treated group (P<0.01). The level of ET was decreased obviously in pravastatin-treated group (P<0.05), while the level of ET in EA-treated group was not changed significantly (P>0.05).
Both EA therapy and pravastatin have efficient regulation of body weight and the content of TC, TG, LDL-C and NO in HLP rats. To some extent, they are able to regulate the imbalance between ET and NO content under the condition of HLP. Western medicine such as pravastatin can regulate the HDL-C level in HLP rats, while the effect of EA therapy on regulation of the HDL-C level is limited.
探讨电针丰隆穴对高脂血症（HLP）大鼠体重、血脂、一氧化氮（NO）及内皮素（ET）的影响。
将80只Wistar大鼠随机分为正常对照组（喂正常饮食）、未治疗组（喂高脂饮食）、电针治疗组（喂高脂饮食加电针治疗）和普伐他汀治疗组（喂高脂饮食加普伐他汀片）。每组20只大鼠。分别于实验前及治疗30天后测量各组大鼠体重及血清总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、NO及ET含量。采用改良心脏穿刺采血法进行采血。
与正常对照组比较，未治疗组大鼠体重及TC、TG、LDL-C、ET水平显著升高（P<0.01，P<0.05），HDL-C及NO水平明显降低（P<0.05）。与未治疗组比较，普伐他汀治疗组和电针治疗组大鼠体重及TC、TG、LDL-C水平显著降低（P<0.01），普伐他汀治疗组和电针治疗组NO含量高于未治疗组（P<0.01）。与未治疗组比较，普伐他汀治疗组HDL-C水平显著升高，电针治疗组HDL-C水平无明显变化，普伐他汀治疗组与电针治疗组HDL-C水平差异有统计学意义（P<0.01）。普伐他汀治疗组ET水平明显降低（P<0.05），电针治疗组ET水平无明显变化（P>0.05）。
电针治疗和普伐他汀均可有效调节HLP大鼠体重及TC、TG、LDL-C和NO含量，在一定程度上可调节HLP状态下ET与NO含量的失衡。普伐他汀等西药可调节HLP大鼠HDL-C水平，而电针治疗调节HDL-C水平的作用有限。
