Mohás Márton, Szigeti Nóra, Markó Lajos, Molnár Gergo A, Cseh Judit, Laczy Boglárka, Tamaskó Mónika, Balla József, Kappelmayer János, Wagner László, Wagner Zoltán, Csiky Botond, Nagy Judit, Wittmann István
2nd Department of Medicine and Nephrological Center, Faculty of Medicine, University of Pécs, Pécs, Hungary.
Kidney Blood Press Res. 2008;31(1):47-54. doi: 10.1159/000112960. Epub 2008 Jan 10.
BACKGROUND/AIMS: Proteinuria, hypoproteinaemia, hypoalbuminaemia and oedema are major characteristics of nephrotic syndrome. Aims of this study were to detect serum total LDH activity and its isozymes in nephrotic syndrome.
In a cross-sectional study, clinical parameters were compared in three cohorts, namely kidney patients with or without nephrotic syndrome and hypoalbuminaemic controls (NEPHR, NON-NEPHR, CONTR, respectively).
Serum total LDH activity in the NEPHR group was increased compared with the NON-NEPHR and CONTR groups (p < 0.001) and correlated with serum total protein (r = -0.549, p < 0.001), serum albumin (r = -0.596, p < 0.001), proteinuria (r = 0.456, p < 0.001) and serum total cholesterol (r = 0.523, p < 0.001). LDH isozyme pattern was analysed in three subgroups of the patients. Serum LDH-2 activity was higher in the NEPHR subgroup compared with the NON-NEPHR and CONTR subgroups (p < 0.001). Serum LDH-2 activity correlated with serum total protein (r = -0.665, p < 0.001), serum albumin (r = -0.615, p < 0.001), proteinuria (r = 0.694, p < 0.001), and serum total cholesterol (r = 0.723, p < 0.001). Linear regression analysis revealed that serum total protein proved to be an independent predictor of serum total LDH activity, while serum total protein and proteinuria were predictors of LDH-2.
These findings suggest that serum total LDH activity might be a marker of the activity of the nephrotic syndrome.
背景/目的：蛋白尿、低蛋白血症、低白蛋白血症和水肿是肾病综合征的主要特征。本研究的目的是检测肾病综合征患者血清总乳酸脱氢酶（LDH）活性及其同工酶。
在一项横断面研究中，比较了三组人群的临床参数，分别为患有或未患有肾病综合征的肾脏疾病患者以及低白蛋白血症对照组（分别为NEPHR、NON-NEPHR、CONTR）。
与NON-NEPHR组和CONTR组相比，NEPHR组血清总LDH活性升高（p < 0.001），且与血清总蛋白（r = -0.549，p < 0.001）、血清白蛋白（r = -0.596，p < 0.001）、蛋白尿（r = 0.456，p < 0.001）和血清总胆固醇（r = 0.523，p < 0.001）相关。对患者的三个亚组进行了LDH同工酶谱分析。与NON-NEPHR亚组和CONTR亚组相比，NEPHR亚组血清LDH-2活性更高（p < 0.001）。血清LDH-2活性与血清总蛋白（r = -0.665，p < 0.001）、血清白蛋白（r = -0.615，p < 0.001）、蛋白尿（r = 0.694，p < 0.001）和血清总胆固醇（r = 0.723，p < 0.001）相关。线性回归分析显示，血清总蛋白是血清总LDH活性的独立预测因子，而血清总蛋白和蛋白尿是LDH-2的预测因子。
这些发现表明血清总LDH活性可能是肾病综合征活动的一个标志物。
