Knowles Charles H
Centre for Academic Surgery, Institute of Cell and Molecular Science, Barts and The London, Queen Mary's School of Medicine & Dentistry, London, UK.
J Pediatr Gastroenterol Nutr. 2007 Dec;45 Suppl 2:S97-102. doi: 10.1097/MPG.0b013e31812e6569.
The term "gastrointestinal neuromuscular disease" can be interpreted variably and encompasses a spectrum of paediatric and adult conditions including achalasia, pseudoobstruction, idiopathic constipation, irritable bowel syndrome, megacolon, and Hirschsprung disease. Although progress has been made in the understanding of the pathophysiology of some conditions, the aetiopathogenesis has been elucidated only in the rare minority. This review critically considers the available evidence for possible pathogenic mechanisms in these disorders.
“胃肠神经肌肉疾病” 这一术语的解释可能多种多样，涵盖了一系列儿科和成人疾病，包括贲门失弛缓症、假性肠梗阻、特发性便秘、肠易激综合征、巨结肠和先天性巨结肠病。尽管在某些疾病的病理生理学理解方面取得了进展，但只有极少数疾病的病因发病机制得到了阐明。本综述批判性地审视了这些疾病中可能的致病机制的现有证据。
