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细胞竞争与癌症有关吗?

Is cell competition relevant to cancer?

作者信息

Moreno Eduardo

机构信息

Spanish National Cancer Centre (CNIO), Melchor Fernández Almagro, 3, E-28029 Madrid, Spain.

出版信息

Nat Rev Cancer. 2008 Feb;8(2):141-7. doi: 10.1038/nrc2252.

Abstract

Cell competition is a type of short-range cell-cell interaction described in Drosophila melanogaster, in which cells expressing different levels of a particular protein are able to discriminate between their relative levels of that protein in such a way that one of the cells disappears from the tissue (the loser), whereas the other (the winner) not only survives but also proliferates to fill the space left by the disappearing cells. Some tumour-promoting mutations are able to induce cell competition in D. melanogaster, but could cell competition become a target for therapeutic intervention, or early detection, in human cancer?

摘要

细胞竞争是在黑腹果蝇中描述的一种短程细胞间相互作用,其中表达特定蛋白质水平不同的细胞能够区分该蛋白质的相对水平,使得其中一个细胞从组织中消失(失败者),而另一个细胞(胜利者)不仅存活,而且增殖以填补消失细胞留下的空间。一些促肿瘤突变能够在黑腹果蝇中诱导细胞竞争,但是细胞竞争能否成为人类癌症治疗干预或早期检测的靶点呢?

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