Division of Gastroenterology, Department of Medicine, Abramson Family Cancer Research Institute, and Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA; email:
Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California, USA; email:
Annu Rev Pathol. 2024 Jan 24;19:397-421. doi: 10.1146/annurev-pathmechdis-031621-025610. Epub 2023 Oct 13.
In the 160 years since Rudolf Virchow first postulated that neoplasia arises by the same law that regulates embryonic development, scientists have come to recognize the striking overlap between the molecular and cellular programs used by cancers and embryos. Advances in cancer biology and molecular techniques have further highlighted the similarities between carcinogenesis and embryogenesis, where cellular growth, differentiation, motility, and intercellular cross talk are mediated by common drivers and regulatory networks. This review highlights the many connections linking cancer biology and developmental biology to provide a deeper understanding of how a tissue's developmental history may both enable and constrain cancer cell evolution.
自鲁道夫·菲尔绍（Rudolf Virchow）首次推测肿瘤的发生遵循调控胚胎发育的同一法则以来，已经过去了 160 年。科学家们逐渐认识到，癌症和胚胎所采用的分子和细胞程序之间存在显著的重叠。癌症生物学和分子技术的进步进一步突出了肿瘤发生和胚胎发生之间的相似性，其中细胞生长、分化、运动和细胞间的相互作用由共同的驱动因素和调控网络介导。这篇综述强调了将癌症生物学和发育生物学联系起来的许多联系，以提供对组织的发育历史如何既能促进又能限制癌细胞进化的更深入理解。
