Baker Nicholas E, Li Wei
Department of Molecular Genetics, Albet Einstein College of Medicine, Bronx, New York 10461, USA.
Cancer Res. 2008 Jul 15;68(14):5505-7. doi: 10.1158/0008-5472.CAN-07-6348.
Cell competition can occur when cells of different genotypes share the same developing compartment, with one genotype displacing the other as a result of a proliferative advantage. Studies of cell competition in Drosophila have identified an active process of cell assassination and corpse engulfment, and also roles for Myc and the Warts/Hippo tumor suppressor pathway. Here, we discuss the possible relevance of cell competition to cancer.
当不同基因型的细胞共享同一个发育区室时，细胞竞争就可能发生，其中一种基因型由于增殖优势而取代另一种基因型。对果蝇细胞竞争的研究已经确定了细胞暗杀和尸体吞噬的活跃过程，以及Myc和Warts/Hippo肿瘤抑制途径的作用。在这里，我们讨论细胞竞争与癌症可能的相关性。
