细胞竞争及其与癌症的可能关系。

Cell competition and its possible relation to cancer.

作者信息

Baker Nicholas E, Li Wei

机构信息

Department of Molecular Genetics, Albet Einstein College of Medicine, Bronx, New York 10461, USA.

出版信息

Cancer Res. 2008 Jul 15;68(14):5505-7. doi: 10.1158/0008-5472.CAN-07-6348.

DOI:10.1158/0008-5472.CAN-07-6348

PMID:18632598

Abstract

Cell competition can occur when cells of different genotypes share the same developing compartment, with one genotype displacing the other as a result of a proliferative advantage. Studies of cell competition in Drosophila have identified an active process of cell assassination and corpse engulfment, and also roles for Myc and the Warts/Hippo tumor suppressor pathway. Here, we discuss the possible relevance of cell competition to cancer.

摘要

当不同基因型的细胞共享同一个发育区室时，细胞竞争就可能发生，其中一种基因型由于增殖优势而取代另一种基因型。对果蝇细胞竞争的研究已经确定了细胞暗杀和尸体吞噬的活跃过程，以及Myc和Warts/Hippo肿瘤抑制途径的作用。在这里，我们讨论细胞竞争与癌症可能的相关性。