Wei Yongzhong, Rector R Scott, Thyfault John P, Ibdah Jamal A
Division of Gastroenterology and Hepatology, Harry S. Truman VA Medical Center, Columbia, MO 65212, United States.
World J Gastroenterol. 2008 Jan 14;14(2):193-9. doi: 10.3748/wjg.14.193.
Nonalcoholic fatty liver disease (NAFLD) includes hepatic steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. NAFLD is the most common liver disorder in the United States and worldwide. Due to the rapid rise of the metabolic syndrome, the prevalence of NAFLD has recently dramatically increased and will continue to increase. NAFLD has also the potential to progress to hepatocellular carcinoma (HCC) or liver failure. NAFLD is strongly linked to caloric overconsumption, physical inactivity, insulin resistance and genetic factors. Although significant progress in understanding the pathogenesis of NAFLD has been achieved in years, the primary metabolic abnormalities leading to lipid accumulation within hepatocytes has remained poorly understood. Mitochondria are critical metabolic organelles serving as "cellular power plants". Accumulating evidence indicate that hepatic mitochondrial dysfunction is crucial to the pathogenesis of NAFLD. This review is focused on the significant role of mitochondria in the development of NAFLD.
非酒精性脂肪性肝病（NAFLD）包括肝脂肪变性、非酒精性脂肪性肝炎（NASH）、纤维化和肝硬化。NAFLD是美国和全球最常见的肝脏疾病。由于代谢综合征的迅速增加，NAFLD的患病率最近急剧上升，并将继续增加。NAFLD也有可能进展为肝细胞癌（HCC）或肝衰竭。NAFLD与热量摄入过多、缺乏运动、胰岛素抵抗和遗传因素密切相关。尽管近年来在理解NAFLD发病机制方面取得了重大进展，但导致肝细胞内脂质积累的主要代谢异常仍知之甚少。线粒体是作为“细胞发电厂”的关键代谢细胞器。越来越多的证据表明，肝脏线粒体功能障碍对NAFLD的发病机制至关重要。本综述重点关注线粒体在NAFLD发展中的重要作用。
