Hayashi S, Sakaguchi T
Tohoku J Exp Med. 1976 May;119(1):91-100. doi: 10.1620/tjem.119.91.
In non-obese but diabetic 15-week-old KK mice which showed fatty liver histopathologically, the content of liver lipids and the levels of blood glucose and plasma IRI were greater than those in the control ICR mice of the same age and were quite similar to those in GTG-obese mice. In 6-week-old KK mice which excreted no glycosuria and showed normal hepatic tissues, only plasma IRI level was slightly elevated as compared with that in the control mice. The cyclic 3',5'-AMP stimulators like epinephrine and theophylline exerted far less potent stimulatory effects on lipolytic activity in 6-week-old KK mice than in the control mice, as in diabetic 15-week-old KK mice and GTG-obese mice. Theophylline potentiated the lipolytic effect of epinephrine lineraly in KK mice, the tendency being different from that in the control mice, and only the submaximal rate was obtained. Furthermore, the inhibitory effect of theophylline on PDE from the epididymal adipose tissue was less potent in 6-week-old KK mice than in healthy ICR mice of the same age.
在15周龄非肥胖但患有糖尿病的KK小鼠中，组织病理学显示存在脂肪肝，其肝脏脂质含量、血糖水平和血浆IRI水平均高于同龄对照ICR小鼠，且与GTG肥胖小鼠相当。在6周龄未出现糖尿且肝脏组织正常的KK小鼠中，与对照小鼠相比，仅血浆IRI水平略有升高。与糖尿病15周龄KK小鼠和GTG肥胖小鼠一样，肾上腺素和茶碱等环3',5'-AMP刺激剂对6周龄KK小鼠脂肪分解活性的刺激作用远低于对照小鼠。茶碱在KK小鼠中线性增强肾上腺素的脂肪分解作用，这一趋势与对照小鼠不同，且仅获得次最大速率。此外，与同龄健康ICR小鼠相比，6周龄KK小鼠中茶碱对附睾脂肪组织磷酸二酯酶的抑制作用较弱。
