萘福昔定（U-11,100A）对子宫过氧化物酶诱导的影响。

Effect of nafoxidine (U-11,100A) on the induction of uterine peroxidase.

作者信息

McNabb T, Jellinck P H

出版信息

Steroids. 1976 May;27(5):681-9. doi: 10.1016/s0039-128x(76)90208-7.

Abstract

The relationship between the quantity of nuclear estrogen receptor complex formed and the amount of peroxidase induced by estradiol in immature rat uteri was determined. A good correlation was obtained between the quantity of 3H-estradiol specifically bound to the nuclear pellet and the amount of enzyme present 12 h after treatment with physiological doses of estrogen. Nafoxidine (U-11,100A) administered together with estrogen reduced signficantly the increase in peroxidase activity brought about by estradiol. Pretreatment with nafoxidine was less effective. The possible mechanism of action of this antiestrogen is discussed.

摘要

测定了未成熟大鼠子宫中形成的核雌激素受体复合物的量与雌二醇诱导的过氧化物酶量之间的关系。用生理剂量雌激素处理12小时后，与核沉淀物特异性结合的3H-雌二醇的量与酶的量之间获得了良好的相关性。与雌激素一起给药的萘福昔定（U-11,100A）显著降低了雌二醇引起的过氧化物酶活性的增加。用萘福昔定预处理效果较差。讨论了这种抗雌激素的可能作用机制。