Izatt J A, Kulkarni M D, Yazdanfar S, Barton J K, Welch A J
Opt Lett. 1997 Sep 15;22(18):1439-41. doi: 10.1364/ol.22.001439.
We describe a novel optical system for bidirectional color Doppler imaging of flow in biological tissues with micrometer-scale resolution and demonstrate its use for in vivo imaging of blood flow in an animal model. Our technique, color Doppler optical coherence tomography (CDOCT), performs spatially localized optical Doppler velocimetry by use of scanning low-coherence interferometry. CDOCT is an extension of optical coherence tomography (OCT), employing coherent signal-acquisition electronics and joint time-frequency analysis algorithms to perform flow imaging simultaneous with conventional OCT imaging. Cross-sectional maps of blood flow velocity with <50-microm spatial resolution and <0.6-mm/s velocity precision were obtained through intact skin in living hamster subdermal tissue. This technology has several potential medical applications.
我们描述了一种用于对生物组织中的血流进行双向彩色多普勒成像的新型光学系统，其具有微米级分辨率，并展示了其在动物模型中对血流进行体内成像的应用。我们的技术——彩色多普勒光学相干断层扫描（CDOCT），通过使用扫描低相干干涉测量法来执行空间定位光学多普勒测速。CDOCT是光学相干断层扫描（OCT）的扩展，采用相干信号采集电子设备和联合时频分析算法，以与传统OCT成像同时进行血流成像。通过活仓鼠皮下组织的完整皮肤，获得了空间分辨率小于50微米且速度精度小于0.6毫米/秒的血流速度横断面图。这项技术有几个潜在的医学应用。
