[富集的神经元和胶质细胞组分中线粒体酶活性的差异]
[Differences in the enzymatic activity of mitochondria from enriched neuronal and glial fractions].
作者信息
Venkov L, Rusanov E
出版信息
Ukr Biokhim Zh. 1976 Mar-Apr;48(2):215-22.
Studies were performed in the activities of certain enzymes from oxidoreductase group: cytochrome c-oxidoreductase (EC 1.6.99.3), succinate dehydrogenase succinates: cytochrome c-oxidoreductase (EC 1.3.99.1), cytochrome oxidase (EC 1.9.3.1) and malate dehydrogenase (EC 1.1.1.37) in mitochondria from neuronal and glial-enriched fractions. The mitochondrial fraction purity was observed by the electron microscope. The enzyme activity of the glial mitochondrial fraction was much higher than that in the neuronal mitochondria. Malate dehydrogenase from glial enriched fraction consists of three isoenzymes, while neuronal mitochondria had two isoenzymes of malate dehydrogenase. The neuronal mitochondria were found to be more stable to lubrol and digitonin.
对来自氧化还原酶组的某些酶的活性进行了研究
细胞色素c氧化还原酶（EC 1.6.99.3）、琥珀酸脱氢酶琥珀酸盐：细胞色素c氧化还原酶（EC 1.3.99.1）、细胞色素氧化酶（EC 1.9.3.1）和苹果酸脱氢酶（EC 1.1.1.37），这些酶存在于富含神经元和神经胶质细胞的线粒体组分中。通过电子显微镜观察线粒体组分的纯度。神经胶质细胞线粒体组分的酶活性远高于神经元线粒体中的酶活性。富含神经胶质细胞组分中的苹果酸脱氢酶由三种同工酶组成，而神经元线粒体中有两种苹果酸脱氢酶同工酶。研究发现，神经元线粒体对十二烷基硫醇和洋地黄皂苷更稳定。
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