Morris Ann C, Scholz Tamera, Fadool James M
Department of Biological Science, Florida State University, Tallahassee, Florida 32306, USA.
Adv Exp Med Biol. 2008;613:361-8. doi: 10.1007/978-0-387-74904-4_42.
The zebrafish is an excellent model organism in which to study the retina's response to photoreceptor degeneration and/or acute injury. While much has been learned about the retinal stem and progenitor cells that mediate the damage response, several questions remain that cannot be addressed by acute models of injury. The development of genetic models, such as the XOPS-mCFP transgenic line, should further efforts to understand the nature of the signals that promote rod progenitor proliferation and differentiation following photoreceptor loss. This in turn may help to refine future approaches in higher vertebrates aimed at enhancing retinal progenitor cell activity for therapeutic purposes.
斑马鱼是一种优秀的模式生物，可用于研究视网膜对光感受器退化和/或急性损伤的反应。虽然我们已经对介导损伤反应的视网膜干细胞和祖细胞有了很多了解，但仍有一些问题无法通过急性损伤模型来解决。遗传模型的开发，如XOPS-mCFP转基因品系，应进一步推动我们对光感受器丧失后促进视杆祖细胞增殖和分化的信号本质的理解。这反过来可能有助于优化未来在高等脊椎动物中旨在增强视网膜祖细胞活性以用于治疗目的的方法。
