Safinia Laleh, Wilson Karen, Mantalaris Athanasios, Bismarck Alexander
Department of Chemical Engineering, Polymer and Composite Engineering (PaCE) Group, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom.
J Biomed Mater Res A. 2008 Dec 1;87(3):632-42. doi: 10.1002/jbm.a.31731.
Pure poly(lactide-co-glycolide) and polystyrene surfaces are not very suitable to support cell adhesion/spreading owing to their hydrophobic nature and low surface energy. The interior surfaces of large porous 3D scaffolds were modified and activated using radio-frequency, low-pressure air plasma. An increase in the wettability of the surface was observed after exposure to air plasma, as indicated by the decrease in the contact angles of the wet porous system. The surface composition of the plasma-treated polymers was studied using X-ray photoelectron spectroscopy. pH-dependent zeta-potential measurements confirm the presence of an increased number of functional groups. However, the plasma-treated surfaces have a less acidic character than the original polymer surfaces as seen by a shift in their isoelectric point. Zeta-potential, as well as contact angle measurements, on 3D scaffolds confirm that plasma treatment is a useful tool to modify the surface properties throughout the interior of large scaffolds.
由于其疏水性和低表面能，纯聚（丙交酯-共-乙交酯）和聚苯乙烯表面不太适合支持细胞粘附/铺展。使用射频、低压空气等离子体对大型多孔3D支架的内表面进行改性和活化。暴露于空气等离子体后，观察到表面润湿性增加，这通过湿多孔系统接触角的减小来表明。使用X射线光电子能谱研究了等离子体处理聚合物的表面组成。pH依赖性zeta电位测量证实了官能团数量的增加。然而，如通过其等电点的移动所见，等离子体处理的表面比原始聚合物表面具有较弱的酸性特征。对3D支架进行的zeta电位以及接触角测量证实，等离子体处理是改变大型支架整个内部表面性质的有用工具。
