Imaizumi Toshio, Honma Toshimi, Horita Yoshifumi, Kawamura Maiko, Kohama Ikuhide, Miyata Kei, Nyon Kim Sang, Niwa Jun
Department of Neurosurgery at Kushiro City General Hospital, Kushiro, Hokkaido, Japan.
J Stroke Cerebrovasc Dis. 2008 Jan-Feb;17(1):30-4. doi: 10.1016/j.jstrokecerebrovasdis.2007.11.001.
Deep intracerebral hematoma (ICH) is frequently associated with microbleed (MB) arising from degenerated MB. Increased numbers of MB are correlated with increased age, and we examined a possible relationship between MB number and ICH onset in younger patients.
Excluding patients with ICH and a history of ICH, we examined the number of MB and other risk factors in 195 patients with deep ICH (97 male, 98 female) consecutively admitted to our hospital. The patients were equally divided into 3 subgroups according to age (groups A, B, and C). Odds ratios were estimated from logistic regression analyses.
The number (percentage) of MB in group A (< or =60 years old, n = 64) 5.0 +/- 9.6 (65.6%) was less than group B (61-69 years old, n = 63) 6.6 +/- 9.1 (79.4%) or group C (> or =70 years old, n = 68) 6.0 +/- 7.0 (86.8%). Multivariate analyses demonstrated that MB greater than or equal to 3 was significantly associated with higher age in group A versus B (odds ratio: 2.3; 95% confidence interval: 1.01-5.3; P = .046) and in group A versus C (odds ratio: 2.6; 95% confidence interval: 1.1-6.2; P =.030).
Our findings suggest that risk factors for the development of ICH may differ with age, and younger patients with deep ICH have fewer MB.
深部脑内血肿（ICH）常与由变性微出血（MB）引起的微出血相关。微出血数量增加与年龄增长相关，我们研究了年轻患者中微出血数量与ICH发病之间的可能关系。
排除有ICH病史的患者，我们对我院连续收治的195例深部ICH患者（97例男性，98例女性）的微出血数量及其他危险因素进行了检查。根据年龄将患者平均分为3个亚组（A组、B组和C组）。通过逻辑回归分析估计比值比。
A组（≤60岁，n = 64）的微出血数量（百分比）为5.0±9.6（65.6%），少于B组（61 - 69岁，n = 63）的6.6±9.1（79.4%）或C组（≥70岁，n = 68）的6.0±7.0（86.8%）。多变量分析表明，A组与B组相比（比值比：2.3；95%置信区间：1.01 - 5.3；P = 0.046）以及A组与C组相比（比值比：2.6；95%置信区间：1.1 - 6.2；P = 0.030），≥3个微出血与较高年龄显著相关。
我们的研究结果表明，ICH发生的危险因素可能因年龄而异，且年轻的深部ICH患者微出血较少。
