脑出血发作时梯度回波T2*加权磁共振图像上微出血灶的数量。

The number of microbleeds on gradient T2*-weighted magnetic resonance image at the onset of intracerebral hemorrhage.

作者信息

Imaizumi Toshio, Honma Toshimi, Horita Yoshifumi, Kawamura Maiko, Kohama Ikuhide, Miyata Kei, Nyon Kim Sang, Niwa Jun

机构信息

Department of Neurosurgery at Kushiro City General Hospital, Kushiro, Hokkaido, Japan.

出版信息

J Stroke Cerebrovasc Dis. 2008 Jan-Feb;17(1):30-4. doi: 10.1016/j.jstrokecerebrovasdis.2007.11.001.

DOI:10.1016/j.jstrokecerebrovasdis.2007.11.001

PMID:18190819

Abstract

OBJECTIVE

Deep intracerebral hematoma (ICH) is frequently associated with microbleed (MB) arising from degenerated MB. Increased numbers of MB are correlated with increased age, and we examined a possible relationship between MB number and ICH onset in younger patients.

METHODS

Excluding patients with ICH and a history of ICH, we examined the number of MB and other risk factors in 195 patients with deep ICH (97 male, 98 female) consecutively admitted to our hospital. The patients were equally divided into 3 subgroups according to age (groups A, B, and C). Odds ratios were estimated from logistic regression analyses.

RESULTS

The number (percentage) of MB in group A (< or =60 years old, n = 64) 5.0 +/- 9.6 (65.6%) was less than group B (61-69 years old, n = 63) 6.6 +/- 9.1 (79.4%) or group C (> or =70 years old, n = 68) 6.0 +/- 7.0 (86.8%). Multivariate analyses demonstrated that MB greater than or equal to 3 was significantly associated with higher age in group A versus B (odds ratio: 2.3; 95% confidence interval: 1.01-5.3; P = .046) and in group A versus C (odds ratio: 2.6; 95% confidence interval: 1.1-6.2; P =.030).

CONCLUSIONS

Our findings suggest that risk factors for the development of ICH may differ with age, and younger patients with deep ICH have fewer MB.

摘要

目的

深部脑内血肿（ICH）常与由变性微出血（MB）引起的微出血相关。微出血数量增加与年龄增长相关，我们研究了年轻患者中微出血数量与ICH发病之间的可能关系。

方法

排除有ICH病史的患者，我们对我院连续收治的195例深部ICH患者（97例男性，98例女性）的微出血数量及其他危险因素进行了检查。根据年龄将患者平均分为3个亚组（A组、B组和C组）。通过逻辑回归分析估计比值比。

结果

A组（≤60岁，n = 64）的微出血数量（百分比）为5.0±9.6（65.6%），少于B组（61 - 69岁，n = 63）的6.6±9.1（79.4%）或C组（≥70岁，n = 68）的6.0±7.0（86.8%）。多变量分析表明，A组与B组相比（比值比：2.3；95%置信区间：1.01 - 5.3；P = 0.046）以及A组与C组相比（比值比：2.6；95%置信区间：1.1 - 6.2；P = 0.030），≥3个微出血与较高年龄显著相关。