Gaudino Rossella, Cavarzere Paolo, Camilot Marta, Teofoli Francesca, Zampieri Nicola, Tatò Luciano
Mother and Child, Biology-Genetics Department, Division of Pediatrics, University of Verona, Verona, Italy.
Fertil Steril. 2008 Dec;90(6):2217-21. doi: 10.1016/j.fertnstert.2007.10.017. Epub 2008 Jan 14.
To investigate the prepubertal serum inhibin B levels in monorchid boys with compensatory testicular hypertrophy (CTH) and in surgically treated cryptorchid boys with normal testicular volume.
Prospective study.
Pediatric Division, University of Verona, Italy.
PATIENT(S): Thirty-two prepubertal boys: 11 monorchids with CTH and 21 cryptorchids. For comparison we analyzed 15 healthy boys.
MAIN OUTCOME MEASURE(S): All patients underwent a GnRH agonist test. Inhibin B measurement was performed at basal time.
RESULT(S): There was a significant difference in mean testicular volume between monorchid and cryptorchid or healthy children, with boys with CTH evidencing larger testicle volume. There was no significant difference in inhibin B levels between boys with CTH and cryptorchid, but the levels were significantly lower in both groups than in the control group. Boys with CTH had significantly higher serum levels of basal FSH than children with cryptorchid. The FSH peak response to GnRH agonist stimulation was significantly higher in boys with CTH than in those with cryptorchid.
CONCLUSION(S): Monorchid infants with CTH showed low inhibin B and high FSH levels. Our finding may confirm the hypothesis that CTH is unable to prevent testicular insufficiency in adulthood. We suggest an early hormonal evaluation of boys with CTH at puberty, together with early sperm analysis.
研究青春期前患代偿性睾丸肥大（CTH）的单侧睾丸男孩以及接受手术治疗且睾丸体积正常的隐睾男孩的血清抑制素B水平。
前瞻性研究。
意大利维罗纳大学儿科。
32名青春期前男孩，其中11名患CTH的单侧睾丸男孩和21名隐睾男孩。作为对照，分析了15名健康男孩。
所有患者均接受促性腺激素释放激素（GnRH）激动剂试验。在基础时间测量抑制素B。
单侧睾丸男孩与隐睾男孩或健康儿童之间的平均睾丸体积存在显著差异，患CTH的男孩睾丸体积更大。患CTH的男孩与隐睾男孩的抑制素B水平无显著差异，但两组的抑制素B水平均显著低于对照组。患CTH的男孩基础促卵泡激素（FSH）血清水平显著高于隐睾儿童。患CTH的男孩对GnRH激动剂刺激的FSH峰值反应显著高于隐睾男孩。
患CTH的单侧睾丸婴儿表现出低抑制素B水平和高FSH水平。我们的发现可能证实了CTH无法预防成年期睾丸功能不全这一假说。我们建议对青春期患CTH的男孩进行早期激素评估，并尽早进行精子分析。
