Vossmann Markus, Kirst Martin, Ludolfs Diana, Schreiber Michael
Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str. 74, 20359 Hamburg, Germany.
Virology. 2008 Apr 10;373(2):322-8. doi: 10.1016/j.virol.2007.12.008. Epub 2008 Jan 14.
The outbreaks of West Nile virus (WNV), an emerging flavivirus recently implicated in outbreaks of fatal encephalitis, necessitate the development of effective anti-WNV drugs. In this study, it is demonstrated that human serum albumin is transformed into a WNV antiviral substance by hypochlorite (HOCl) modification. The HOCl-modified albumin efficiently neutralized WNV in vitro (EC50=300 nM) and showed binding to a recombinant protein, representing the domain III of the WNV external envelope E glycoprotein.
西尼罗河病毒（WNV）是一种新出现的黄病毒，最近与致命性脑炎的爆发有关，其爆发使得开发有效的抗WNV药物成为必要。在本研究中，证明了人血清白蛋白通过次氯酸盐（HOCl）修饰转化为一种WNV抗病毒物质。HOCl修饰的白蛋白在体外能有效中和WNV（EC50=300 nM），并显示出与一种重组蛋白结合，该重组蛋白代表WNV外膜E糖蛋白的结构域III。
