Volk Talila, Israeli David, Nir Ronit, Toledano-Katchalski Hila
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.
Trends Genet. 2008 Feb;24(2):94-101. doi: 10.1016/j.tig.2007.11.009. Epub 2008 Jan 14.
The regulation of developmental processes at the RNA level enables selective and rapid modulation of gene expression. Studies in model organisms revealed the essential contribution of the signal transduction and activation of RNA (STAR) family of RNA binding proteins to developmental processes. STAR proteins coordinate the proper timing of developmental events by delaying expression or altering the mRNA or protein levels of essential genes. Recent functional analysis of the Drosophila melanogaster STAR protein, Held Out Wing (HOW), in the context of embryonic development, provided insight into its mode of activity. Here, we describe HOW's activity in the temporal repression or elevation of gene expression that is essential for coordinating the correct timing of instructive signals.
RNA水平上发育过程的调控能够实现对基因表达的选择性快速调节。对模式生物的研究揭示了RNA结合蛋白的信号转导和RNA激活（STAR）家族对发育过程的重要贡献。STAR蛋白通过延迟表达或改变关键基因的mRNA或蛋白质水平来协调发育事件的正确时间。最近，在胚胎发育背景下对果蝇STAR蛋白“展开翅膀”（HOW）的功能分析，为其活性模式提供了深入了解。在这里，我们描述了HOW在基因表达的时间抑制或增强中的活性，这对于协调指导性信号的正确时间至关重要。
