由转座元件起始的人类顺式天然反义转录本。

Human cis natural antisense transcripts initiated by transposable elements.

作者信息

Conley Andrew B, Miller Wolfgang J, Jordan I King

机构信息

School of Biology, Georgia Institute of Technology, Atlanta, GA 30306, USA.

出版信息

Trends Genet. 2008 Feb;24(2):53-6. doi: 10.1016/j.tig.2007.11.008. Epub 2008 Jan 14.

DOI:10.1016/j.tig.2007.11.008

PMID:18192066

Abstract

The capacity of human transposable elements (TEs) to promote cis natural antisense transcripts (cis-NATs) is revealed by the discovery of 48,718 human gene antisense transcriptional start sites (TSSs) within TE sequences. TSSs that yield cis-NATs are overrepresented among TE sequences, and TE-initiated cis-NATs are more abundant close to the 3' ends of genes. The TE sequences that promote antisense transcription within human genes are relatively ancient, suggesting that selection has acted to conserve their function.

摘要

在转座元件（TEs）序列中发现48,718个人类基因反义转录起始位点（TSSs），这揭示了人类转座元件促进顺式天然反义转录本（cis-NATs）的能力。产生顺式天然反义转录本的转录起始位点在转座元件序列中过度富集，并且由转座元件起始的顺式天然反义转录本在基因的3'端附近更为丰富。在人类基因中促进反义转录的转座元件序列相对古老，这表明选择作用使其功能得以保留。