Kaufmann-Bart M, Fischer I
Institute of Veterinary Pathology, Vetsuisse Faculty Zurich, Switzerland.
Vet Pathol. 2008 Jan;45(1):77-9. doi: 10.1354/vp.45-1-77.
A 3-year-old female rabbit (Oryctolagus cuniculi) presented with apathy and indisposition for 2-3 days. Palpation revealed a mass in the caudal abdomen, namely, in the wall of the uterus. Ovariohysterectomy was performed, and the tissues were submitted for histopathologic examination. The mass consisted of 3 different (trophoblastic, syncytiotrophoblastic, and cytotrophoblastic) neoplastic cell types originating from the uterus. Immunohistochemistry was positive for cytokeratin in all 3 neoplastic cell types, and the syncytiotrophoblasts were positive also for human chorionic gonadotropin. Together these features allow the diagnosis choriocarcinoma. This report documents the first case of a spontaneous choriocarcinoma in a rabbit.
一只3岁雌性家兔（穴兔）出现冷漠和不适症状2 - 3天。触诊发现尾腹部有一肿块，位于子宫壁。进行了卵巢子宫切除术，并将组织送去做组织病理学检查。该肿块由源自子宫的3种不同（滋养层、合体滋养层和细胞滋养层）肿瘤细胞类型组成。免疫组化显示所有3种肿瘤细胞类型的细胞角蛋白均为阳性，合体滋养层细胞的人绒毛膜促性腺激素也为阳性。综合这些特征可诊断为绒毛膜癌。本报告记录了首例家兔自发性绒毛膜癌病例。
