Bowen W H
University of Rochester, Department of Dental Research.
Adv Dent Res. 1991 Dec;5:46-9. doi: 10.1177/08959374910050010601.
Although the prevalence of caries has declined in young persons in developed countries, there is still a need for water fluoridation. The effectiveness of fluoride is dependent on the ambient levels of fluoride in the oral cavity. Fluoride appears to exert the bulk of its protective effect locally by promoting remineralization of early carious lesions. Nevertheless, fluoride tablets continue to be prescribed as if the action of fluoride is expressed systemically. There is an urgent need to explore the clearance of fluoride from the mouth and to develop methods to ensure constant levels of fluoride in the oral cavity, thereby reducing both the need for frequent exposure and the amount necessary for clinical effect.
尽管发达国家年轻人的龋齿患病率有所下降，但仍有必要进行水氟化。氟化物的有效性取决于口腔中氟化物的环境水平。氟化物似乎主要通过促进早期龋损的再矿化在局部发挥其保护作用。然而，氟化物片剂仍在被处方，就好像氟化物的作用是全身性的一样。迫切需要探索口腔中氟化物的清除情况，并开发方法以确保口腔中氟化物水平恒定，从而减少频繁接触的必要性以及临床效果所需的剂量。
