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尽管采用局部抗代谢药物治疗结膜癌，但仍发生眼眶侵犯。

Orbital invasion despite topical anti-metabolite therapy for conjunctival carcinoma.

作者信息

Char Devron H, Crawford J Brooks

机构信息

The Tumori Foundation, 45 Castro Street, Suite 309, San Francisco, CA 94114, USA.

出版信息

Graefes Arch Clin Exp Ophthalmol. 2008 Mar;246(3):459-61. doi: 10.1007/s00417-007-0742-y. Epub 2008 Jan 12.

DOI:10.1007/s00417-007-0742-y
PMID:18193262
Abstract

BACKGROUND

Two cases of conjunctival carcinoma developed orbital invasion during treatment with topical medication.

METHODS

This was a retrospective study from a tertiary ophthalmic oncology unit, performed after informed consent was obtained. The main outcome measurement was orbital invasion.

RESULTS

Two patients treated with topical agents developed orbital invasion.

CONCLUSION

While topical agents are important in treatment of conjunctival neoplasia, recurrence or deep invasion require careful monitoring.

摘要

背景

两例结膜癌患者在局部用药治疗期间发生眼眶侵犯。

方法

这是一项来自三级眼科肿瘤科室的回顾性研究，在获得知情同意后进行。主要观察指标为眼眶侵犯。

结果

两名接受局部用药治疗的患者发生了眼眶侵犯。

结论

虽然局部用药在结膜肿瘤的治疗中很重要，但复发或深部侵犯需要仔细监测。

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本文引用的文献

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Eyelid melanoma with negative sentinel lymph node biopsy and perineural spread.前哨淋巴结活检阴性且有神经周围扩散的眼睑黑色素瘤
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Role of topical chemotherapy for primary acquired melanosis and malignant melanoma of the conjunctiva and cornea: review of the evidence and recommendations for treatment.
局部化疗在结膜和角膜原发性获得性黑变病及恶性黑色素瘤中的作用：证据综述与治疗建议
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Complications of mitomycin C therapy in 100 eyes with ocular surface neoplasia.100例眼表肿瘤患者丝裂霉素C治疗的并发症
Br J Ophthalmol. 2006 Jul;90(7):819-22. doi: 10.1136/bjo.2005.086850. Epub 2006 May 3.
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Topical mitomycin chemotherapy for conjunctival malignant melanoma and primary acquired melanosis with atypia: clinical experience with histopathologic observations.局部丝裂霉素化疗治疗结膜恶性黑色素瘤和原发性获得性黑色素沉着伴异型性：组织病理学观察的临床经验
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Topical 5-fluorouracil in treating epithelial neoplasia of the conjunctiva and cornea.局部应用5-氟尿嘧啶治疗结膜和角膜上皮肿瘤。
Ophthalmology. 1995 Sep;102(9):1338-44. doi: 10.1016/s0161-6420(95)30866-4.
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Topical application of 5-fluorouracil in premalignant lesions of cornea, conjunctiva and eyelid.
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