Poothullil Antony M, Colby Kathryn A
Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA.
Semin Ophthalmol. 2006 Jul-Sep;21(3):161-9. doi: 10.1080/08820530500351694.
We review the use of three topical medications for the therapy of ocular surface tumors: mitomycin C, 5-fluorouracil, and interferon alpha-2B. One hundred sixty patients with histologically or cytologically proven epithelial and melanocytic tumors were identified in the literature. Side effects occurred most often with mitomycin C, followed by 5-fluorouracil, and interferon alpha-2B. Patients most frequently experienced transient keratitis, redness, and irritation. Topical agents were used as both primary and adjuvant therapy. Rates of tumor regression for CIN and squamous cell carcinoma ranged from 80 to 96%, and 70% of pigmented tumors regressed after an average follow-up of 27 months.
丝裂霉素C、5-氟尿嘧啶和干扰素α-2B。在文献中确定了160例经组织学或细胞学证实的上皮性和黑素细胞性肿瘤患者。副作用最常发生于丝裂霉素C，其次是5-氟尿嘧啶，然后是干扰素α-2B。患者最常出现短暂性角膜炎、眼红和刺激症状。局部用药用作主要治疗和辅助治疗。CIN（宫颈上皮内瘤变）和鳞状细胞癌的肿瘤消退率为80%至96%，色素性肿瘤在平均随访27个月后70%出现消退。
