Mironov Vladimir, Kasyanov Vladimir, Markwald Roger R, Prestwich Glenn D
Medical University of South Carolina, Charleston, SC 29425, USA.
Expert Opin Biol Ther. 2008 Feb;8(2):143-52. doi: 10.1517/14712598.8.2.143.
Casting is a process by which a material is introduced into a mold while it is liquid, allowed to solidify in a predefined shape inside the mold, and then removed to give a fabricated object, part or casing. Centrifugal casting could be defined as a process of molding using centrifugal forces. Although the centrifugal casting technology has a long history in metal manufacturing and in the plastics industry, only recently has this technology attracted the attention of tissue engineers. Initially, centrifugation was used to optimize cell seeding on a solid scaffold. More recently, centrifugal casting has been used to create tubular scaffolds and both tubular and flat multilayered, living tissue constructs. These newer applications were enabled by a new class of biocompatible in situ crosslinkable hydrogels that mimic the extracellular matrix. Herein the authors summarize the state of the art of centrifugal casting technology in tissue engineering, they outline associated technological challenges, and they discuss the potential future for clinical applications.
铸造是一种将材料在液态时引入模具，使其在模具内凝固成预定形状，然后取出以得到制成品、部件或外壳的工艺。离心铸造可定义为利用离心力进行成型的工艺。尽管离心铸造技术在金属制造和塑料工业中有着悠久的历史，但直到最近该技术才引起组织工程学家的关注。最初，离心用于优化细胞在固体支架上的接种。最近，离心铸造已被用于制造管状支架以及管状和平坦的多层活体组织构建体。这些新应用是由一类新型的模拟细胞外基质的生物相容性原位可交联水凝胶实现的。在此，作者总结了组织工程中离心铸造技术的现状，概述了相关的技术挑战，并讨论了其临床应用的潜在未来。
