阿尔茨海默病患者的教育程度与症状出现情况
Education and reported onset of symptoms among individuals with Alzheimer disease.
作者信息
Roe Catherine M, Xiong Chengjie, Grant Elizabeth, Miller J Phillip, Morris John C
机构信息
Division of Biostatistics, Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, Missouri 63108, USA.
出版信息
Arch Neurol. 2008 Jan;65(1):108-11. doi: 10.1001/archneurol.2007.11.
Abstract
OBJECTIVES
To examine whether reported age at onset of dementia symptoms among participants with Alzheimer disease (AD) is later for those with fewer years of education and, if so, to see if education is attributed to delayed detection of symptoms.
DESIGN
Case series.
SETTING
National Alzheimer's Coordinating Center Minimum Data Set (N=21 880 participants) and Washington University Alzheimer's Disease Research Center (N=1449 participants).
RESULTS
Reported age at onset of dementia symptoms is slightly younger in participants with more education. Participants with fewer years of education show greater clinical severity of Alzheimer disease at first assessment.
CONCLUSION
Symptoms of Alzheimer disease are recognized later among those with less education.
摘要
目的
研究阿尔茨海默病（AD）患者中，报告的痴呆症状发病年龄对于受教育年限较少的患者是否更晚出现；如果是，探究教育程度是否归因于症状检测延迟。
设计
病例系列研究。
地点
国家阿尔茨海默病协调中心最小数据集（N = 21880名参与者）和华盛顿大学阿尔茨海默病研究中心（N = 1449名参与者）。
结果
受教育程度较高的参与者报告的痴呆症状发病年龄略小。受教育年限较少的参与者在首次评估时阿尔茨海默病的临床严重程度更高。
结论
受教育程度较低的人群中，阿尔茨海默病症状的识别较晚。
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本文引用的文献
1
Apolipoprotein Eepsilon4 modifies Alzheimer's disease onset in an E280A PS1 kindred.
Ann Neurol. 2003 Aug;54(2):163-9. doi: 10.1002/ana.10636.
2
An autopsy-verified study of the effect of education on degenerative dementia.
Brain. 1999 Dec;122 ( Pt 12):2309-19. doi: 10.1093/brain/122.12.2309.
3
Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype.
Arch Neurol. 1998 Mar;55(3):326-35. doi: 10.1001/archneur.55.3.326.
4
Association of education with reported age of onset and severity of Alzheimer's disease at presentation: implications for the use of clinical samples.
Am J Epidemiol. 1993 Feb 15;137(4):456-62. doi: 10.1093/oxfordjournals.aje.a116694.
5
The Clinical Dementia Rating (CDR): current version and scoring rules.
Neurology. 1993 Nov;43(11):2412-4. doi: 10.1212/wnl.43.11.2412-a.
6
Influence of education and occupation on the incidence of Alzheimer's disease.
JAMA. 1994 Apr 6;271(13):1004-10.
7
The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects.
Br J Psychiatry. 1968 Jul;114(512):797-811. doi: 10.1192/bjp.114.512.797.
8
"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician.
J Psychiatr Res. 1975 Nov;12(3):189-98. doi: 10.1016/0022-3956(75)90026-6.
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