Department of Sociology, Yale University, New Haven, CT 06520, USA.
Department of Biostatistics, Yale University, New Haven, CT 06520, USA.
Age Ageing. 2022 Jun 1;51(6). doi: 10.1093/ageing/afac139.
physical functioning impairment is common among persons with cognitive impairment, but little is known about physical functioning trajectories across the US population or how trajectories may differ among persons with dementia and mild cognitive impairment (MCI).
to examine trajectories of physical functioning among persons with MCI and dementia in the USA.
we used data from the National Health and Aging Trends study (NHATS) 2011-18. Physical functioning was assessed using the NHATS Expanded Short Physical Performance Battery.
the 661 individuals with MCI and 980 individuals with dementia were included in this study.
we applied group-based trajectory models to identify latent groups and estimate their trajectories. Multinomial logistic regressions were applied to examine relationships between sociodemographic and health characteristics and trajectory group memberships.
both MCI- and dementia-specific trajectories differed at baseline levels and declined at varying rates across groups. Approximately, 78.43% of persons with MCI were in trajectories with a moderate rate of decline, with only 9.75% in a trajectory with good physical function and 11.82% with poor physical function without as much change over time. Among persons with dementia, approximately 81.4% experienced moderate or fast declines, and 18.52% with virtually no functional ability remained at this same low level. Worse physical functioning trajectories were found among persons who were females, Blacks, with at least four comorbidities, and among persons who had a low socioeconomic status.
persons with both dementia and MCI experienced steady declines in physical functioning. Socioeconomically disadvantaged groups have worse physical functioning trajectories.
认知障碍患者普遍存在身体功能障碍，但人们对美国人群的身体功能轨迹知之甚少，也不清楚痴呆症和轻度认知障碍（MCI）患者的身体功能轨迹有何不同。
研究美国 MCI 和痴呆症患者的身体功能轨迹。
我们使用了来自国家健康老龄化趋势研究（NHATS）2011-18 年的数据。使用 NHATS 扩展短期体能电池来评估身体功能。
本研究纳入了 661 名 MCI 患者和 980 名痴呆症患者。
我们应用基于群组的轨迹模型来确定潜在群组并估计其轨迹。应用多项逻辑回归来检验社会人口学和健康特征与轨迹组别的关系。
MCI 和痴呆症特定的轨迹在基线水平上有所不同，并且在不同组别中以不同的速度下降。大约 78.43%的 MCI 患者处于功能中等程度下降的轨迹，只有 9.75%的患者处于功能良好的轨迹，11.82%的患者处于功能较差的轨迹，而且随着时间的推移没有太多变化。在痴呆症患者中，大约 81.4%的患者经历了中度或快速下降，18.52%的患者几乎没有功能能力，而且一直保持在这个较低的水平。身体功能较差的轨迹与女性、黑人、至少有四种合并症以及社会经济地位较低的人群有关。
痴呆症和 MCI 患者的身体功能都在稳步下降。社会经济地位较低的群体的身体功能轨迹更差。
