Tander Berna, Gunes Sezgin, Boke Omer, Alayli Gamze, Kara Nurten, Bagci Hasan, Canturk Ferhan
Department of Physical Medicine and Rehabilitation, Ondokuzmayis University School of Medicine, 55139 Kurupelit, Samsun, Turkey.
Rheumatol Int. 2008 May;28(7):685-91. doi: 10.1007/s00296-008-0525-8. Epub 2008 Jan 15.
Genetic and environmental factors are thought to play roles in the etiopathology of fibromyalgia syndrome (FMS). The objective of this study was to determine the potential effects of single nucleotide polymorphisms (SNPs) in catechol-O-methyltransferase (COMT) (rs4680) and 5-hydroxytryptamine (serotonin) 2A (5-HT2A) receptor (rs6313 and rs6311) genes on susceptibility to FMS. One hundred seventy-one women (80 FMS, 91 control) were enrolled in the study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used for the genotyping analyses. Genotype and allele frequencies were calculated by the chi-square test. Beck depression inventory, state and trait anxiety inventory and symptom checklist-90 revised (SCL-90-R) tests were applied to both patients and controls. There were no observed differences in the frequencies of alleles and genotypes between patients and controls for the COMT, and the two 5-HT2A receptor gene polymorphisms (P>0.05). Our results suggest that the investigated polymorphisms seem not to be the susceptibility factors in etiology of FMS.
遗传和环境因素被认为在纤维肌痛综合征（FMS）的病因病理中发挥作用。本研究的目的是确定儿茶酚-O-甲基转移酶（COMT）基因（rs4680）和5-羟色胺（血清素）2A（5-HT2A）受体基因（rs6313和rs6311）中的单核苷酸多态性（SNP）对FMS易感性的潜在影响。171名女性（80例FMS患者，91例对照）参与了本研究。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法进行基因分型分析。通过卡方检验计算基因型和等位基因频率。对患者和对照均应用贝克抑郁量表、状态和特质焦虑量表以及症状自评量表90修订版（SCL-90-R）测试。COMT以及两个5-HT2A受体基因多态性在患者和对照之间的等位基因和基因型频率未观察到差异（P>0.05）。我们的结果表明，所研究的多态性似乎不是FMS病因中的易感因素。
