Yildiz Saliha Handan, Ulaşli Alper Murat, Özdemir Erdoğan Müjgan, Dikici Ömer, Arikan Terzi Evrim Suna, Dündar Ümit, Solak Mustafa
Department of Medical Genetics, Medical Faculty of Afyon Kocatepe University, Afyonkarahisar, Turkey.
Department of Physical Medicine and Rehabilitation, Medical Faculty of Afyon Kocatepe University, Afyonkarahisar, Turkey.
Arch Rheumatol. 2016 Aug 17;32(1):3-9. doi: 10.5606/ArchRheumatol.2017.5846. eCollection 2017 Mar.
This study aims to investigate the association of two common HTR2A gene polymorphisms, rs6313 (102 T/C) and rs6311 (1438 A/G), with chronic low back pain (CLBP) and the pain threshold, disability, and sex differences.
A total of 121 patients (40 males, 81 females; mean age 36.8±9.9 years; range 18 to 50 years) having CLBP and 91 healthy controls (26 males, 65 females; mean age 34.1±10.2 years; range 18 to 55 years) were included. Pressure pain thresholds (PPTs) of all participants were examined with manual algometer in certain sites of their body.
The PPTs were all decreased in CLBP patients (p<0.05). Although PPTs were lower in healthy female subjects, there was no sex difference regarding PPTs in CLBP patients (p>0.05). rs6311 polymorphism of HTR2A gene was associated with CLBP (p<0.05). In rs6313 polymorphism, at least one copy of T carriers and in rs6311 polymorphism, at least one copy of G carriers showed higher disability.
The PPT decreases in CLBP patients similar to other chronic pain conditions without any sex difference. Although rs6311 single nucleotide polymorphism of HTR2A gene was associated with CLBP and rs6313 polymorphism was not, rs6311 might have a protective effect on disability of these patients.
本研究旨在探讨5-羟色胺受体2A（HTR2A）基因的两种常见多态性rs6313（102T/C）和rs6311（1438A/G）与慢性下腰痛（CLBP）以及疼痛阈值、残疾情况和性别差异之间的关联。
纳入了121例患有CLBP的患者（40例男性，81例女性；平均年龄36.8±9.9岁；年龄范围18至50岁）和91例健康对照者（26例男性，65例女性；平均年龄34.1±10.2岁；年龄范围18至55岁）。使用手动压力痛觉计检查了所有参与者身体特定部位的压力痛阈值（PPT）。
CLBP患者的PPT均降低（p<0.05）。尽管健康女性受试者的PPT较低，但CLBP患者在PPT方面不存在性别差异（p>0.05）。HTR2A基因的rs6311多态性与CLBP相关（p<0.05）。在rs6313多态性中，至少携带一个T拷贝的携带者以及在rs6311多态性中，至少携带一个G拷贝的携带者表现出更高的残疾程度。
CLBP患者的PPT降低，与其他慢性疼痛情况类似，且不存在性别差异。尽管HTR2A基因的rs6311单核苷酸多态性与CLBP相关，而rs6313多态性与之无关，但rs6311可能对这些患者的残疾具有保护作用。
