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骨科手术中使用冷冻同种异体骨移植的随访研究:菲利普·D·威尔逊医学博士(1886 - 1969)。1934年美国骨科医师学会第三任主席。

Follow-up study of the use of refrigerated homogenous bone transplants in orthopaedic operations : Philip D. Wilson MD (1886-1969). The 3rd president of the AAOS 1934.

作者信息

Wilson Philip D

出版信息

Clin Orthop Relat Res. 2008 Jan;466(1):22-36. doi: 10.1007/s11999-007-0030-5.

Abstract

Philip Duncan Wilson was born in Columbus, Ohio. His father was a family physician who held the Chair of Obstetrics in the Sterling Medical School [1]. The young Philip graduated from Harvard College in 1909 and then served as President of his graduating class at Harvard Medical School. He spent two years as a surgical intern at MGH, after which he returned to Columbus to practice. During WWI he was invited back to Boston to join the Harvard Unit under Harvey Cushing, and served with that unit when it was housed in the Lycée Pasteur. (The members of that unit included Marius Smith-Petersen, who also spent many years at the Massachusetts General Hospital and also became AAOS President.) He rejoined MGH on the staff in 1919. In 1925 he published an influential monograph with W.A. Cochrane (formerly of the Edinburgh Royal Infirmary), entitled, “Fractures and Dislocations” [5]. Toward the end of his years in Boston he helped found the American Academy of Orthopaedic Surgeons. In 1934 he was appointed as Surgeon-in-Chief at the Hospital for the Ruptured and Crippled in New York City. Dr. Wilson was active in many organizations, and reorganized and renamed the hospital he served (Hospital for Special Surgery), oversaw the building of a new hospital at its current site on the Cornell University medical campus, and raised money for a large research building. His zest inspired generations, and he was known for his gracious hospitality. Dr. Wilson was one of three of the first fifteen Presidents (the others being Drs. John C. Wilson, Sr. and Melvin Henderson) whose son (Dr. Philip D. Wilson, Jr.) succeeded him as a President of the American Academy of Orthopaedic Surgeons. Dr. Wilson had a long interest in bone grafting and wrote numerous research papers, a few of which are referenced here [2–4]. In the article reprinted in this issue [3], he described the rapid increase in use of a bone bank he developed at the Hospital for Special Surgery in 1946: 19 operations using grafts in 1946, 48 in 1947, 106 in 1948, 134 in 1949, and 259 in 1950. He describes his animal experiments with autogenous grafts in which grafts rapidly incorporated. He further describes biopsies of previously implanted autogenous and homogenous bone transplants in patients undergoing serial fusions for scoliosis. The pathologist (Dr. Milton Helpern) commented they found “...no evidence that the cells in the bone transplants survived...” Autogenous grafts, his evidence suggested, incorporated more rapidly that homogenous grafts, but “...in the end the results are the same.” His followup studies suggested successful incorporation of graft in 210 of 248 cases. [Figure: see text] 1. Philip Duncan Wilson, MD 1886–1969. . 1969;51:1445–1447. 2. Wilson PD. Experiences with a bone bank. . 1947;126:932–945. 3. Wilson PD. Experience with the use of refrigerated homogenous bone. . 1951;33:301–315. 4. Wilson PD. Follow-up study of the use of refrigerated homogenous bone grafts in orthopaedic operations. . 1951;33:307–323. 5. Wilson PD, Cochrane WA. . Philadelphia, PA: JB Lippincott; 1925.

摘要

菲利普·邓肯·威尔逊出生于俄亥俄州的哥伦布市。他的父亲是一名家庭医生,担任斯特林医学院妇产科主任[1]。年轻的菲利普于1909年毕业于哈佛大学,随后担任哈佛医学院毕业班的班长。他在麻省总医院做了两年外科实习医生,之后回到哥伦布市行医。第一次世界大战期间,他被邀请回到波士顿,加入哈维·库欣领导的哈佛医疗队,并在该医疗队驻扎在巴斯德中学时服役。(该医疗队的成员包括马吕斯·史密斯 - 彼得森,他也在麻省总医院工作了多年,后来还成为了美国骨科医师学会主席。)1919年,他重新加入麻省总医院工作。1925年,他与W.A. 科克伦(原爱丁堡皇家医院医生)发表了一篇有影响力的专著,题为《骨折与脱位》[5]。在他在波士顿的职业生涯接近尾声时,他帮助创立了美国骨科医师学会。1934年,他被任命为纽约市破裂与伤残医院的外科主任。威尔逊医生活跃于许多组织,他对自己工作的医院进行了重组并重新命名(特殊外科医院),监督了在康奈尔大学医学园区现址建造新医院的工作,并为一座大型研究楼筹集资金。他的热情激励了几代人,他以热情好客而闻名。威尔逊医生是前十五任主席中的三位(另外两位是约翰·C. 威尔逊医生和梅尔文·亨德森医生),他们的儿子(小菲利普·D. 威尔逊医生)继任成为美国骨科医师学会主席。威尔逊医生长期对骨移植感兴趣,并撰写了许多研究论文,这里引用了其中几篇[2 - 4]。在本期重印的文章[3]中,他描述了他于1946年在特殊外科医院建立的骨库使用量的快速增长:1946年使用移植骨进行了19例手术,1947年为48例,1948年为106例,1949年为134例,1950年为259例。他描述了他用自体移植骨进行的动物实验,其中移植骨迅速融合。他还进一步描述了对接受脊柱侧凸系列融合手术患者先前植入的自体和同种异体骨移植进行活检的情况。病理学家(米尔顿·赫尔珀恩医生)评论说,他们发现“……没有证据表明骨移植中的细胞存活……”。他的证据表明,自体移植骨比同种异体移植骨融合得更快,但“……最终结果是相同的”。他的随访研究表明,248例病例中有210例移植成功融合。[图:见原文] 1. 菲利普·邓肯·威尔逊,医学博士,1886 - 1969年。... 1969;51:1445 - 1447。2. 威尔逊PD。骨库的经验。... 1947;126:932 - 945。3. 威尔逊PD。冷藏同种异体骨的使用经验。... 1951;33:301 - 315。4. 威尔逊PD。骨科手术中冷藏同种异体骨移植使用的随访研究。... 1951;33:307 - 323。5. 威尔逊PD,科克伦WA。... 宾夕法尼亚州费城:JB利平科特出版社;1925年。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12f5/2505281/e399e080ab00/11999_2007_30_Figa_HTML.jpg

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