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先天性髋关节脱位的病因:卡尔·E·巴杰利医学博士(1893 - 1973)。1942年美国骨科医师学会第11任主席。

Etiology of congenital dislocation of the hip : Carl E. Badgley MD (1893-1973). The 11th president of the AAOS 1942.

作者信息

Badgley Carl E

出版信息

Clin Orthop Relat Res. 2008 Jan;466(1):90-103. doi: 10.1007/s11999-007-0020-7.

Abstract

Dr. Carl E. Badgley was born in 1893, the son of a Presbyterian minister [2]. He received his medical degree at the University of Michigan in 1919, and became interested in orthopaedic surgery owing to Drs. Hugh Cabot and LeRoy Abbott. He was appointed as an instructor of surgery in 1920 and was appointed professor and head of the Section of Orthopaedic Surgery in 1932, an appointment he retained until 1963 when he retired. Dr. Badgley, devoted to his home state, was active in organizing institutions and organizations within Michigan. These included the Rackham Arthritis Research Unit within the hospital devoted exclusively to arthritis research and the Michigan Crippled Children Commission. He was active in the Board of Control of Intercollegiate Athletics. As President of the AAOS in 1942, he faced challenges organizing the 1943 meeting owing to the war years and many parts of the social program, particularly for the spouses, were eliminated [3]. (Travel was limited in part due to rationing of gas and a reduction in some public transportation since the war effort had priority on petroleum products.) Of the 235 members and 461 guests attending the 11 Annual Meeting in 1943, 203 of the men were in the military service. Nonetheless, during his year of Presidency of the AAOS, Instructional Course Lectures (13 courses) were introduced at the 1942 annual meeting (at a cost of $1.00 per course) and were an immediate success [3]. They were first published the following year (1943) by J.W. Edwards Co., of Ann Arbor, Michigan (who continued to publish the ICL through 1958), under the editorship of a future AAOS President, Dr. Tommy Thomson. The article we reproduce here details the two major theories of congenital dislocation of the hip: “a primary germinal fault…(and)…a defect of development of environmental origin” [1]. As a true scientist, he commented, “The most commonly accepted theory of developmental abnormality is a primary failure of proper formation of the acetabulum, particularly a germinal failure of development of the posterior superior buttress of the ilium…It is difficult to see how an observer, unless influenced by the weight of pre-existing statements and concepts, can authoritatively state a hypothesis as an accepted fact. The author denies dogmatically, for example, that there is scientific evidence of a primary genetic developmental fault of the posterior superior portion of the acetabulum. He does not refute the existence of such a lesion, but contends that no satisfactory evidence has been submitted that this lesion is the primary developmental fault.” How often do we make our judgments based on the “weight of preexisting statements,” rather than compelling observations and data? Also as a true scientist, his thorough review leads to and ends with a hypothesis: “Congenital dislocation and congenital dysplasia of the hip may be regarded as the result of faulty development, due to environmental factors extrinsic to the hip joint. An inherited fault in the timing of development may produce these extrinsic changes… Heredity can play an important part in altering the growth and time factors.” Despite astonishing technical advances, we have the same working hypothesis today and DDH may indeed be related to the timing of genetically controlled events in conjunction with external factors; the details of the genetic factors are being explored with tools not available to Dr. Badgley, but we seem no closer to the larger answer. [Figure: see text] 1. Badgley CE. Etiology of congenital dislocation of the hip. . 1949;31:341–356. 2. Carl E. Badgley, M.D. 1893–1973.. 1973;55:1112–1113. 3. Heck CV.. Chicago, IL: American Academy of Orthopaedic Surgeons; 1983.

摘要

卡尔·E·巴杰利医生于1893年出生,是一位长老会牧师之子[2]。1919年,他在密歇根大学获得医学学位,由于休·卡伯特医生和勒罗伊·阿博特医生的缘故,他对骨科手术产生了兴趣。1920年,他被任命为外科教员,1932年被任命为骨科手术科教授兼主任,他一直担任这一职务直至1963年退休。巴杰利医生热爱自己的家乡密歇根州,积极参与该州各类机构和组织的组建工作。这些机构包括医院内专门从事关节炎研究的拉克姆关节炎研究单位以及密歇根残疾儿童委员会。他还活跃于校际体育管理委员会。1942年,作为美国骨科医师学会主席,由于处于战争年代,他在组织1943年的会议时面临诸多挑战,许多社交活动项目,尤其是为配偶安排的项目都被取消了[3]。(旅行受限部分原因是汽油实行配给制,且由于战争对石油产品有优先需求,一些公共交通也有所减少。)在1943年参加第11届年会的235名会员和461名嘉宾中,有203名男性正在服兵役。尽管如此,在他担任美国骨科医师学会主席的那一年,1942年的年会上引入了教学课程讲座(共13门课程,每门课程收费1美元),并立即获得成功[3]。这些讲座次年(1943年)由密歇根州安阿伯市的J.W.爱德华兹公司首次出版(该公司一直出版教学课程讲座直至1958年),由未来的美国骨科医师学会主席汤米·汤姆森医生担任编辑。我们在此转载的这篇文章详细阐述了先天性髋关节脱位的两种主要理论:“原发性胚层缺陷……(以及)……环境起源的发育缺陷”[1]。作为一名真正的科学家,他评论道:“发育异常最被广泛接受的理论是髋臼正常形成的原发性失败,尤其是髂骨后上支撑结构发育的胚层失败……很难想象,一个观察者,除非受到既有观点和概念的影响,如何能权威性地将一种假设当作已被接受的事实。例如,作者坚决否认有科学证据表明髋臼后上部分存在原发性遗传发育缺陷。他并不否认这种病变的存在,但认为没有提交令人满意的证据证明这种病变是原发性发育缺陷。”我们基于“既有观点的影响”而非令人信服的观察和数据来做出判断的情况有多常见呢?同样作为一名真正的科学家,他全面的综述得出并以一个假设作为结尾:“先天性髋关节脱位和先天性髋关节发育不良可被视为发育异常的结果,这是由于髋关节外部的环境因素导致的。发育时间上的遗传缺陷可能会产生这些外部变化……遗传因素在改变生长和时间因素方面可能起到重要作用。”尽管技术取得了惊人的进步,但我们如今仍有相同的工作假设,发育性髋关节发育不良可能确实与基因控制事件的时间以及外部因素有关;基因因素的细节正通过巴杰利医生当时无法获得的工具进行探索,但我们似乎仍未更接近那个更大的答案。[图:见原文] 1. 巴杰利CE。先天性髋关节脱位的病因。. 1949;31:341 - 356。2. 卡尔·E·巴杰利,医学博士。1893 - 1973。. 1973;55:1112 - 1113。3. 赫克CV。. 伊利诺伊州芝加哥:美国骨科医师学会;1983。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6bb/2505289/8b2e530fa4ad/11999_2007_20_Figa_HTML.jpg

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