Chilton F H, Cluzel M, Triggiani M
Johns Hopkins University School of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224.
Lipids. 1991 Dec;26(12):1021-7. doi: 10.1007/BF02536495.
In the last few years, it has become increasingly apparent that the biochemistry of PAF (platelet-activating factor) and that of arachidonic acid are interrelated in a number of inflammatory cells. Experiments presented here further point out that arachidonic acid plays a crucial role in the catabolism and biosynthesis of PAF. In addition, they suggest that the same phospholipid molecular species may serve as a source for both arachidonic acid and 1-alkyl-2-lyso-sn-glycero-3-phosphocholine during cell activation. Finally, they reveal that there may be common regulatory mechanisms for the biosynthesis of PAF and arachidonic acid metabolites. Taken together, studies examining the relationship between PAF and arachidonic acid suggest it may be difficult to consider the biochemistry of PAF without considering arachidonic acid metabolism and vice versa.
在过去几年中，越来越明显的是，血小板活化因子（PAF）的生物化学与花生四烯酸的生物化学在许多炎症细胞中相互关联。此处展示的实验进一步指出，花生四烯酸在PAF的分解代谢和生物合成中起着关键作用。此外，这些实验表明，在细胞活化过程中，相同的磷脂分子种类可能同时作为花生四烯酸和1-烷基-2-溶血-sn-甘油-3-磷酸胆碱的来源。最后，这些实验揭示，PAF和花生四烯酸代谢产物的生物合成可能存在共同的调节机制。综上所述，研究PAF与花生四烯酸之间关系的实验表明，如果不考虑花生四烯酸代谢，就很难研究PAF的生物化学，反之亦然。
