Denizot Y, Michel L, Benveniste J, Meybeck A, Thomas Y, Dubertret L
INSERM U.200, Clamart, France.
Lipids. 1991 Dec;26(12):1093-4. doi: 10.1007/BF02536508.
Paf is a phospholipid mediator present in human skin which induces inflammatory events, such as neutrophil infiltration and increased vascular permeability. Recent data suggest that cutaneous cells, such as fibroblasts and keratinocytes, produce paf and that paf is released during allergic cutaneous reactions. It is tempting to speculate that paf may contribute to the development of various skin disorders with acute and chronic skin inflammation. Paf antagonists may help in bringing answers to this hypothesis and may offer new prospects for the treatment of cutaneous inflammatory diseases.
血小板活化因子（PAF）是一种存在于人体皮肤中的磷脂介质，可引发炎症反应，如中性粒细胞浸润和血管通透性增加。最近的数据表明，皮肤细胞，如成纤维细胞和角质形成细胞，可产生PAF，且PAF在过敏性皮肤反应期间释放。人们不禁推测，PAF可能在各种伴有急慢性皮肤炎症的皮肤疾病的发展中起作用。PAF拮抗剂可能有助于证实这一假设，并可能为皮肤炎症性疾病的治疗提供新的前景。
