血清白蛋白、吲哚美辛和组胺H1拮抗剂对实验动物和人类皮肤中血小板活化因子诱导的炎症反应的影响。
Effects of serum albumin, indomethacin and histamine H1-antagonists on Paf-acether-induced inflammatory responses in the skin of experimental animals and man.
作者信息
Archer C B, MacDonald D M, Morley J, Page C P, Paul W, Sanjar S
出版信息
Br J Pharmacol. 1985 May;85(1):109-13. doi: 10.1111/j.1476-5381.1985.tb08836.x.
Cutaneous responses to synthetic platelet activating factor (Paf-acether) have been studied in guinea-pig and human skin. Intradermal injection of Paf-acether elicited an acute inflammatory response in guinea-pig skin (assessed by means of radioisotopic techniques) and acute oedema formation in human skin (assessed by means of weal volume and flare area). Acute inflammatory responses in guinea-pig and human skin are potentiated by the presence of serum albumin, a phospholipid carrier. Acute inflammatory responses induced by Paf-acether in guinea-pig and human skin are not significantly affected by concomitant administration of the cyclo-oxygenase inhibitor, indomethacin. Acute inflammatory responses induced by Paf-acether in guinea-pig and human skin are not significantly affected by concomitant administration of the cyclo-oxygenase inhibitor, indomethacin. Acute inflammatory responses induced by Paf-acether in guinea-pig and human skin are slightly modified by the H1-receptor antagonists, mepyramine and chlorpheniramine. These results indicate that the acute inflammatory response induced by Paf-acether is independent of cyclo-oxygenase products of arachidonic acid and that histamine release has a minor contribution to the inflammatory response induced by Paf-acether.
已在豚鼠和人体皮肤中研究了对合成血小板激活因子（血小板激活因子乙醚）的皮肤反应。皮内注射血小板激活因子乙醚在豚鼠皮肤中引发急性炎症反应（通过放射性同位素技术评估），在人体皮肤中引发急性水肿形成（通过风团体积和红晕面积评估）。血清白蛋白（一种磷脂载体）的存在会增强豚鼠和人体皮肤中的急性炎症反应。血小板激活因子乙醚在豚鼠和人体皮肤中诱导的急性炎症反应不受同时给予环氧化酶抑制剂吲哚美辛的显著影响。组胺H1受体拮抗剂美吡拉敏和氯苯那敏会对血小板激活因子乙醚在豚鼠和人体皮肤中诱导的急性炎症反应产生轻微影响。这些结果表明，血小板激活因子乙醚诱导的急性炎症反应独立于花生四烯酸的环氧化酶产物，并且组胺释放在血小板激活因子乙醚诱导的炎症反应中起次要作用。
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