Sverrisdóttir Yrsa Bergmann, Mogren Tove, Kataoka Josefin, Janson Per Olof, Stener-Victorin Elisabet
Institute of Neuroscience and Physiology, Dept. of Physiology, Sahlgrenska Academy, Göteborg Univ., Box 432, SE-405 30 Göteborg, Sweden.
Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E576-81. doi: 10.1152/ajpendo.00725.2007. Epub 2008 Jan 15.
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disturbance among women of reproductive age and is proposed to be linked with size at birth and increased prevalence of cardiovascular disease. A disturbance in the sympathetic nervous system may contribute to the etiology of PCOS. This study evaluates sympathetic outflow in PCOS and its relation to size at birth. Directly recorded sympathetic nerve activity to the muscle vascular bed (MSNA) was obtained in 20 women with PCOS and in 18 matched controls. Ovarian ultrasonographic evaluation, biometric, hormonal, and biochemical parameters were measured, and birth data were collected. Women with PCOS had increased MSNA (30 +/- 8 vs. 20 +/- 7 burst frequency, P < 0.0005) compared with controls. MSNA was positively related to testosterone (r = 0.63, P < 0.005) and cholesterol (r = 0.55, P = 0.01) levels in PCOS, which, in turn, were not related to each other. Testosterone level was a stronger predictor of MSNA than cholesterol. Birth size did not differ between the study groups. This is the first study to directly address sympathetic nerve activity in women with PCOS and shows that PCOS is associated with high MSNA. Testosterone and cholesterol levels are identified as independent predictors of MSNA in PCOS, although testosterone has a stronger impact. The increased MSNA in PCOS may contribute to the increased cardiovascular risk and etiology of the condition. In this study, PCOS was not related to size at birth.
多囊卵巢综合征（PCOS）是育龄女性中常见的内分泌和代谢紊乱疾病，据推测与出生时的体重及心血管疾病患病率增加有关。交感神经系统紊乱可能在PCOS的病因中起作用。本研究评估了PCOS患者的交感神经输出及其与出生时体重的关系。对20例PCOS女性患者和18例匹配的对照组进行了直接记录的肌肉血管床交感神经活动（MSNA）测定。测量了卵巢超声评估、生物统计学、激素和生化参数，并收集了出生数据。与对照组相比，PCOS女性患者的MSNA增加（爆发频率分别为30±8次/分钟和20±7次/分钟，P<0.0005）。在PCOS患者中，MSNA与睾酮水平（r = 0.63，P<0.005）和胆固醇水平（r = 0.55，P = 0.01）呈正相关，而睾酮水平和胆固醇水平之间无相关性。睾酮水平比胆固醇水平是MSNA更强的预测指标。研究组之间出生时的体重无差异。这是第一项直接研究PCOS女性患者交感神经活动的研究，结果表明PCOS与高MSNA有关。睾酮和胆固醇水平被确定为PCOS患者MSNA的独立预测指标，尽管睾酮的影响更强。PCOS患者增加的MSNA可能导致心血管风险增加及该疾病的病因。在本研究中，PCOS与出生时的体重无关。
