Vanky Eszter, Isaksen Hege, Moen Mette Haase, Carlsen Sven M
Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway.
Acta Obstet Gynecol Scand. 2008;87(5):531-5. doi: 10.1080/00016340802007676.
To investigate the breastfeeding rate in new mothers with polycystic ovary syndrome (PCOS).
Case-control study. Thirty-six women with PCOS and 99 controls matched for age, gestational length and parity, answered a questionnaire. Breastfeeding at one-, three- and six-months postpartum was registered and the two groups were compared. In the women with PCOS, androgen levels through pregnancy were analysed and related to breastfeeding rate.
At one-month postpartum, 27 (75%) of the women with PCOS were breastfeeding exclusively, whereas five (14%) did not breastfeed at all. Among controls, 88 (89%) were breastfeeding exclusively and two (2%) did not breastfeed (p=0.001). At three- and six-months postpartum, breastfeeding was equal in the two groups. Problems with sore nipples and seeking professional lactation support were also equal. Dehydroepiandrosterone-sulphate levels at gestational week 32 and 36 showed a weak negative association with breastfeeding in PCOS women. Breastfeeding rate was not associated with maternal gestational levels of androstenedione, testosterone, sex-hormone binding globulin, or free testosterone index in PCOS.
Women with PCOS appear to have a reduced breastfeeding rate in the early postpartum period. Possibly, gestational dehydroepiandrosterone-sulphate might negatively influence breastfeeding rate in women with the syndrome.
调查多囊卵巢综合征（PCOS）新妈妈的母乳喂养率。
病例对照研究。36名患有PCOS的女性和99名年龄、孕周和产次匹配的对照者回答了一份问卷。记录产后1个月、3个月和6个月时的母乳喂养情况，并对两组进行比较。在患有PCOS的女性中，分析孕期雄激素水平并将其与母乳喂养率相关联。
产后1个月时，27名（75%）患有PCOS的女性纯母乳喂养，而5名（14%）根本没有母乳喂养。在对照组中，88名（89%）纯母乳喂养，2名（2%）没有母乳喂养（p=0.001）。产后3个月和6个月时，两组的母乳喂养情况相同。乳头疼痛问题和寻求专业泌乳支持的情况也相同。孕32周和36周时硫酸脱氢表雄酮水平与PCOS女性的母乳喂养呈弱负相关。PCOS患者的母乳喂养率与孕期母体雄烯二酮、睾酮、性激素结合球蛋白或游离睾酮指数水平无关。
患有PCOS的女性在产后早期的母乳喂养率似乎较低。孕期硫酸脱氢表雄酮可能会对患有该综合征的女性的母乳喂养率产生负面影响。
