Travagli Valter, Zanardi Iacopo, Boschi Letizia, Gabbrielli Alessandro, Mastronuzzi Vita A M, Cappelli Roberto, Forconi Sandro
Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Italy.
Clin Hemorheol Microcirc. 2008;38(2):65-74.
The absence of a simple and clinically practical method to determine whole blood viscosity can partly justify why the medical community has been slow in realizing the significance of whole blood viscosity. For this reason, the availability of a technique able to evaluate blood viscosity in a rapid and direct manner is welcome. To evaluate the feasibility in hemorheological laboratory of a new torsional oscillation viscometer, it was compared with a conventional cone-plate system. The viscosity comparison has been related to hematocrit value both on whole blood and suspended blood in a saline solution. The results showed a good repeatability and reproducibility of the new equipment, with a best-fitting data of the hematocrit 0-100% range characterized by coefficient of determinations, r2>0.95. Furthermore, a comparison of whole blood viscosity as measured by the two instruments was done on blood samples collected from hospitalized patients. Reasonable agreement for the viscosity values was found between the two methods with linear determination coefficients between the two measurement methods comprised between r2=0.7329 and 0.9263, depending on shear stress phase and the corresponding shear rate.
缺乏一种简单且临床实用的方法来测定全血粘度，这在一定程度上可以解释为何医学界在认识全血粘度的重要性方面进展缓慢。因此，一种能够快速、直接评估血液粘度的技术受到欢迎。为了评估新型扭转振荡粘度计在血液流变学实验室中的可行性，将其与传统的锥板系统进行了比较。在全血和盐溶液悬浮血液中，粘度比较均与血细胞比容值相关。结果表明，新设备具有良好的重复性和再现性，血细胞比容0 - 100%范围的最佳拟合数据的决定系数r2>0.95。此外，对从住院患者采集的血样，用这两种仪器测量全血粘度进行了比较。两种方法测得的粘度值存在合理的一致性，两种测量方法之间的线性决定系数在r2 = 0.7329至0.9263之间，这取决于剪切应力阶段和相应的剪切速率。
