Dubrovina N I, Zinov'ev D R
Ross Fiziol Zh Im I M Sechenova. 2007 Nov;93(11):1285-91.
The dependence of activation and blockade of GABA receptors influences on extinction of passive avoidance response from a type of receptors and initial psychoemotional state of mice is shown. The activation of GABAA receptors by muscimol disrupted extinction in norm and did not influence on delay of this process at mice with "behavioral despair". The activation of GABAB receptors by baclofen accelerated extinction of fair memory at mice with depressive-like state. The blockade of GABAA receptors by bicuculline was ineffective in modification of extinction. The blockade of GABAB receptors by phaclofen promoted retention of fear expression at intact mice and facilitation of extinction at "depressive" mice.
研究表明，GABA受体的激活和阻断对被动回避反应消退的影响取决于受体类型和小鼠的初始心理情绪状态。蝇蕈醇激活GABAA受体破坏了正常情况下的消退过程，而对处于“行为绝望”状态的小鼠的这一过程延迟没有影响。巴氯芬激活GABAB受体加速了处于抑郁样状态小鼠的消退记忆。荷包牡丹碱阻断GABAA受体对消退的改变无效。法氯芬阻断GABAB受体促进了正常小鼠恐惧表达的保留，并促进了“抑郁”小鼠的消退。
