Walden P A, Bagshawe K D
Am J Obstet Gynecol. 1976 Aug 15;125(8):1108-14. doi: 10.1016/0002-9378(76)90816-4.
The reproductive performance of 36 women who had been successfully treated for gestational trophoblastic tumors with multiple courses of cytotoxic agents including methotrexate, 6-mercaptopurine, actinomycin D, and 6-azauridine, between 1962 and 1972, has been studied in comparison with 36 patients who had spontaneously aborted a hydatidiform mole but received no treatment and a control group consisting of 36 women attending an antenatal clinic. The majority of patients who wanted further pregnancies following chemotherapy had one or more successful conceptions. The incidence of abnormal pregnancies in the treated group was higher than that of the control group. Similarly, there was a higher number of abnormal pregnancies in the untreated mole patients when compared with the control group. This suggests that patients who develop trophoblastic tumors tend to have a poor obstetric history and that this is not significantly worsened by chemotherapy.
1962年至1972年间，对36名曾接受包括甲氨蝶呤、6-巯基嘌呤、放线菌素D和6-氮尿苷在内的多疗程细胞毒性药物成功治疗妊娠滋养细胞肿瘤的女性的生殖性能进行了研究，并与36名自然流产葡萄胎但未接受治疗的患者以及由36名产前检查门诊女性组成的对照组进行了比较。大多数化疗后希望再次怀孕的患者有一次或多次成功受孕。治疗组异常妊娠的发生率高于对照组。同样，与对照组相比，未治疗的葡萄胎患者中异常妊娠的数量也更多。这表明发生滋养细胞肿瘤的患者往往有不良产科史，且化疗不会使其明显恶化。
