Gordon Robert T, Schatz Carole Beck, Myers Lawrence J, Kosty Michael, Gonczy Constance, Kroener Joan, Tran Michael, Kurtzhals Pamela, Heath Susan, Koziol James A, Arthur Nan, Gabriel Madeline, Hemping Judy, Hemping Gordon, Nesbitt Sally, Tucker-Clark Lydia, Zaayer Jennifer
Department of Obstetrics and Gynecology, Scripps Clinic, La Jolla, CA 92130, USA.
J Altern Complement Med. 2008 Jan-Feb;14(1):61-7. doi: 10.1089/acm.2006.6408.
To determine whether canines could be trained to identify patients with cancer by sniffing the urine obtained from a patient with breast or prostate cancer from among samples obtained from healthy volunteers.
Dogs of different breeds were trained by their owners to detect the urine sample from a patient with cancer from among 6 other age- and sex-matched healthy volunteers. After the training was completed, using new samples, 2 test runs were used for each patient with breast cancer and three runs for the patients with prostate cancer against the same matched samples. The configuration of the samples was different for each run. A total of 18 and 33 runs were carried out, respectively.
For each cohort, specificity and sensitivity were measured. In the breast cancer tests, of 6 dogs, only 2 performed better than chance in specificity and none were more sensitive than chance. For the prostate sample testing, 4 dogs were used. Two performed significantly better than chance in specificity and none in sensitivity.
Although this study did not produce the outcomes desired, the literature supports a potential to use canines for human cancer detection. Better management of urine samples and a more stringent training protocol during our study may have provided new evidence as to the feasibility of using canines for cancer detection. A comparison of the 3 dog cancer scenting studies is also presented.
确定是否可以训练犬类通过从健康志愿者的样本中嗅出乳腺癌或前列腺癌患者的尿液来识别癌症患者。
不同品种的犬由其主人训练，从另外6名年龄和性别匹配的健康志愿者中检测出癌症患者的尿液样本。训练完成后，使用新样本，对每位乳腺癌患者进行2次测试，对前列腺癌患者进行3次测试，与相同的匹配样本进行对比。每次测试样本的排列组合都不同。分别共进行了18次和33次测试。
对每个队列测量特异性和敏感性。在乳腺癌测试中，6只犬中只有2只的特异性表现优于随机水平，没有一只的敏感性高于随机水平。在前列腺样本测试中，使用了4只犬。2只的特异性表现优于随机水平，没有一只的敏感性高于随机水平。
尽管本研究未得出预期结果，但文献支持犬类用于人类癌症检测的潜力。在我们的研究中，更好地管理尿液样本和采用更严格的训练方案可能会为犬类用于癌症检测的可行性提供新证据。还对三项犬类癌症嗅探研究进行了比较。
