Zhou L M, Xu J M, Chen X H, Xie Y S
Department of Medicine, Shanghai Ninth People's Hospital, Shanghai Second Medical University, China.
Zhongguo Yao Li Xue Bao. 1991 Sep;12(5):465-7.
Guan-fu base A (GA), an alkaloid first isolated in China, 50 mg.L-1 decreased the action potential amplitude and the maximal rate of depolarization (Vmax) of guinea pig papillary muscles in vitro. GA shortened the action potential period at 90% repolarization (APD90) without significant effect on the effective refractory period (ERP), resulting in an increased ERP/APD90 ratio. GA 50 mg.L-1 also slowed the conduction speed. The inhibiting effect of GA on Vmax showed frequency- and potential-dependent manners.
关附甲素（GA）是一种最早在中国分离得到的生物碱，50mg.L-1可降低豚鼠乳头肌的动作电位幅度和最大去极化速率（Vmax）。GA可缩短动作电位复极化90%时程（APD90），而对有效不应期（ERP）无显著影响，导致ERP/APD90比值升高。50mg.L-1的GA还可减慢传导速度。GA对Vmax的抑制作用呈频率和电位依赖性。
