Wang Q S, Yin J X, Liu T F
Department of Physiology, Zhang-jiakou Medical College, China.
Zhongguo Yao Li Xue Bao. 1990 Mar;11(2):143-6.
The electrophysiological action of nicotine was studied by microelectrode technique on isolated guinea pig and rabbit papillary muscles. Nicotine had no significant effect on RP, APA and Vmax; but its biphasic effect on APD35, APD90 and ERP were observed in different concentrations, ie: high concentration (604 mumols/L) prolonged APD35, APD90 and ERP by 27.3, 26.0 and 26.1% respectively, whereas low concentration (0.6 mumol/L) shortened them by 49.6, 40.0 and 27.6%, respectively. It is suggested that high concentration of nicotine may enhance the calcium influx, but low concentration decrease it.
采用微电极技术，在离体豚鼠和家兔乳头肌上研究了尼古丁的电生理作用。尼古丁对静息电位（RP）、动作电位幅度（APA）和最大上升速率（Vmax）无明显影响；但在不同浓度下观察到其对35%动作电位时程（APD35）、90%动作电位时程（APD90）和有效不应期（ERP）具有双相作用，即：高浓度（604μmol/L）时，APD35、APD90和ERP分别延长27.3%、26.0%和26.1%，而低浓度（0.6μmol/L）时，它们分别缩短49.6%、40.0%和27.6%。提示高浓度尼古丁可能增强钙内流，而低浓度则减少钙内流。
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