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年轻可卡因使用者中的精神疾病共病:诱发型与独立型障碍

Psychiatric comorbidity in young cocaine users: induced versus independent disorders.

作者信息

Herrero M Jesús, Domingo-Salvany Antonia, Torrens Marta, Brugal M Teresa

机构信息

Health Services Research Unit (IMIM-Hospital del Mar), Barcelona, Spain.

出版信息

Addiction. 2008 Feb;103(2):284-93. doi: 10.1111/j.1360-0443.2007.02076.x.

Abstract

AIMS

To examine the psychiatric status of young cocaine users using a validated instrument for the evaluation of psychiatric comorbidity, emphasizing the distinction between independent and induced psychiatric conditions.

DESIGN

Cross-sectional study.

SETTING

Barcelona, Spain.

PARTICIPANTS

A cohort of 139 young (18-30 years) adult current regular cocaine users.

MEASUREMENTS

The Psychiatric Research Interview for Substance and Mental Disorders (PRISM-IV, which produces diagnoses according to DSM-IV criteria, including Axis II antisocial and borderline personality disorders).

FINDINGS

Nearly 42.5% of the subjects presented psychiatric comorbidity. The most common Axis I diagnoses were mood disorders (26.6%) and anxiety disorders (13%). Increasing age, having ever received treatment for drug use and freebase cocaine use were associated with substance-induced disorders diagnoses relative to primary Axis I disorders.

CONCLUSIONS

This study has shown a relatively high prevalence of psychiatric comorbidity in cocaine users recruited in non-clinical settings. Future studies examining potential differential factors associated with primary versus substance-induced disorders are necessary to optimize the implementation of more suitable approaching programmes for young regular cocaine users.

摘要

目的

使用一种经过验证的用于评估精神疾病共病的工具,检查年轻可卡因使用者的精神状态,强调独立精神疾病与诱发精神疾病之间的区别。

设计

横断面研究。

地点

西班牙巴塞罗那。

参与者

139名年龄在18至30岁之间的成年当前定期使用可卡因的年轻使用者队列。

测量方法

物质与精神障碍的精神病学研究访谈(PRISM-IV,根据《精神疾病诊断与统计手册》第四版标准进行诊断,包括第二轴反社会和边缘性人格障碍)。

研究结果

近42.5%的受试者存在精神疾病共病。最常见的第一轴诊断是情绪障碍(26.6%)和焦虑障碍(13%)。相对于原发性第一轴疾病,年龄增长、曾接受过药物使用治疗以及使用快克可卡因与物质诱发障碍的诊断相关。

结论

本研究表明,在非临床环境中招募的可卡因使用者中,精神疾病共病的患病率相对较高。未来有必要开展研究,探讨与原发性疾病和物质诱发疾病相关的潜在差异因素,以优化针对年轻定期可卡因使用者实施更合适的治疗方案。

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