巴西结核病患者的体液免疫反应表明其对结核分枝杆菌MPT-51和GlcB具有识别能力。
Humoral immune responses of tuberculosis patients in Brazil indicate recognition of Mycobacterium tuberculosis MPT-51 and GlcB.
作者信息
Melo Cardoso Almeida Cristina, Vasconcelos Arioldo C, Kipnis André, Andrade Ana Lúcia, Junqueira-Kipnis Ana Paula
机构信息
Departamento de Microbiologia, Imunologia, Parasitologia e Patologia, Laboratório de Imunopatologia das Doenças Infecciosas, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia-Go, Brasil.
出版信息
Clin Vaccine Immunol. 2008 Mar;15(3):579-81. doi: 10.1128/CVI.00359-07. Epub 2008 Jan 16.
Abstract
The humoral responses to recombinant MPT-51 and GlcB was determined by using an enzyme-linked immunosorbent assay. Levels of immunoglobulin M (IgM) against MPT-51 and IgG against GlcB were higher among tuberculosis (TB) patients than among control individuals. When the MPT-51 and GlcB assays were combined, 90.8% specificity and 75.5% sensitivity were observed. MPT-51 and GlcB were recognized in the humoral responses of Brazilian TB patients.
摘要
通过酶联免疫吸附测定法确定对重组MPT - 51和GlcB的体液免疫反应。结核病（TB）患者中针对MPT - 51的免疫球蛋白M（IgM）水平和针对GlcB的IgG水平高于对照个体。当将MPT - 51和GlcB检测相结合时，观察到特异性为90.8%，敏感性为75.5%。在巴西结核病患者的体液免疫反应中识别出了MPT - 51和GlcB。
相似文献
1
Humoral immune responses of tuberculosis patients in Brazil indicate recognition of Mycobacterium tuberculosis MPT-51 and GlcB.巴西结核病患者的体液免疫反应表明其对结核分枝杆菌MPT-51和GlcB具有识别能力。
Clin Vaccine Immunol. 2008 Mar;15(3):579-81. doi: 10.1128/CVI.00359-07. Epub 2008 Jan 16.
2
Humoral response to HspX and GlcB to previous and recent infection by Mycobacterium tuberculosis.针对结核分枝杆菌既往和近期感染，机体对HspX和GlcB的体液免疫反应。
BMC Infect Dis. 2007 Dec 31;7:148. doi: 10.1186/1471-2334-7-148.
3
Antibody response in pulmonary tuberculosis against recombinant 27kDa (MPT51, Rv3803c) protein of Mycobacterium tuberculosis.肺结核中针对结核分枝杆菌重组27kDa（MPT51，Rv3803c）蛋白的抗体反应。
Scand J Infect Dis. 2007;39(10):867-74. doi: 10.1080/00365540701402954.
4
Generation of Mycobacterium tuberculosis-specific recombinant antigens and evaluation of the clinical value of antibody detection for serological diagnosis of pulmonary tuberculosis.结核分枝杆菌特异性重组抗原的制备及其在结核分枝杆菌血清学诊断中应用价值的评估。
Int J Mol Med. 2013 Mar;31(3):751-7. doi: 10.3892/ijmm.2013.1254. Epub 2013 Jan 22.
5
Health care workers humoral immune response against GLcB, MPT51 and HSPX from Mycobacterium tuberculosis.结核分枝杆菌 GLcB、MPT51 和 HSPX 对卫生保健工作者体液免疫应答的影响
Braz J Infect Dis. 2009 Dec;13(6):417-21. doi: 10.1590/s1413-86702009000600006.
6
Cellular responses to MPT-51, GlcB and ESAT-6 among MDR-TB and active tuberculosis patients in Brazil.巴西耐多药结核病患者和活动性肺结核患者对MPT-51、GlcB和ESAT-6的细胞反应。
Tuberculosis (Edinb). 2008 Sep;88(5):474-81. doi: 10.1016/j.tube.2008.06.002. Epub 2008 Jul 26.
7
8
Antibody markers of incident tuberculosis among HIV-infected adults in the USA: a historical prospective study.美国HIV感染成人中新发结核病的抗体标志物：一项历史性前瞻性研究。
Int J Tuberc Lung Dis. 2007 Jun;11(6):624-31.
9
Antibody response to four secretory proteins from Mycobacterium tuberculosis and their complex antigen in TB patients.结核病患者对结核分枝杆菌四种分泌蛋白及其复合抗原的抗体反应。
Int J Tuberc Lung Dis. 2005 Dec;9(12):1327-34.
引用本文的文献
1
A MAPS Vaccine Induces Multipronged Systemic and Tissue-Resident Cellular Responses and Protects Mice against Mycobacterium tuberculosis.一种 MAPS 疫苗可诱导多效性全身性和组织驻留细胞应答，并保护小鼠免受结核分枝杆菌感染。
mBio. 2023 Feb 28;14(1):e0361122. doi: 10.1128/mbio.03611-22. Epub 2023 Feb 7.
2
Immunogenicity of a recombinant Mycobacterium smegmatis vaccine expressing the fusion protein CMX in cattle from Goiás State, Brazil.在巴西戈亚斯州牛群中表达融合蛋白CMX的重组耻垢分枝杆菌疫苗的免疫原性。
J Vet Med Sci. 2014 Jul;76(7):977-84. doi: 10.1292/jvms.13-0338. Epub 2014 Mar 31.
3
Prime-boost with Mycobacterium smegmatis recombinant vaccine improves protection in mice infected with Mycobacterium tuberculosis.用耻垢分枝杆菌重组疫苗进行初免-加强免疫可提高感染结核分枝杆菌小鼠的保护力。
PLoS One. 2013 Nov 8;8(11):e78639. doi: 10.1371/journal.pone.0078639. eCollection 2013.
4
Immunogenicity of a fusion protein containing immunodominant epitopes of Ag85C, MPT51, and HspX from Mycobacterium tuberculosis in mice and active TB infection.结核分枝杆菌 Ag85C、MPT51 和 HspX 免疫优势表位融合蛋白在小鼠和活动性结核感染中的免疫原性。
PLoS One. 2012;7(10):e47781. doi: 10.1371/journal.pone.0047781. Epub 2012 Oct 25.
5
Development of an ELISA to detect Sin Nombre virus-specific IgM from deer mice (Peromyscus maniculatus).一种用于检测鹿鼠（白足鼠）中汉他病毒特异性 IgM 的酶联免疫吸附测定法的开发。
J Virol Methods. 2008 Aug;151(2):204-210. doi: 10.1016/j.jviromet.2008.05.008. Epub 2008 Jun 30.
本文引用的文献
1
Antibodies to mycobacterial antigens for diagnosis of tuberculosis.用于结核病诊断的抗分枝杆菌抗原抗体。
FEMS Immunol Med Microbiol. 2007 Dec;51(3):453-61. doi: 10.1111/j.1574-695X.2007.00302.x. Epub 2007 Oct 17.
2
Antibody response in pulmonary tuberculosis against recombinant 27kDa (MPT51, Rv3803c) protein of Mycobacterium tuberculosis.肺结核中针对结核分枝杆菌重组27kDa（MPT51，Rv3803c）蛋白的抗体反应。
Scand J Infect Dis. 2007;39(10):867-74. doi: 10.1080/00365540701402954.
3
Progress in serodiagnosis of Mycobacterium tuberculosis infection.结核分枝杆菌感染血清学诊断的进展
Scand J Immunol. 2007 Aug-Sep;66(2-3):176-91. doi: 10.1111/j.1365-3083.2007.01978.x.
4
Commercial serological antibody detection tests for the diagnosis of pulmonary tuberculosis: a systematic review.用于诊断肺结核的商业血清学抗体检测试验：一项系统评价
PLoS Med. 2007 Jun;4(6):e202. doi: 10.1371/journal.pmed.0040202.
5
Antibody markers of incident tuberculosis among HIV-infected adults in the USA: a historical prospective study.美国HIV感染成人中新发结核病的抗体标志物：一项历史性前瞻性研究。
Int J Tuberc Lung Dis. 2007 Jun;11(6):624-31.
6
Mycobacterium tuberculosis malate synthase- and MPT51-based serodiagnostic assay as an adjunct to rapid identification of pulmonary tuberculosis.基于结核分枝杆菌苹果酸合酶和MPT51的血清学诊断检测作为快速诊断肺结核的辅助手段
Clin Vaccine Immunol. 2006 Nov;13(11):1291-3. doi: 10.1128/CVI.00158-06.
7
Enhanced patient serum immunoreactivity to recombinant Mycobacterium tuberculosis CFP32 produced in the yeast Pichia pastoris compared to Escherichia coli and its potential for serodiagnosis of tuberculosis.与在大肠杆菌中产生的重组结核分枝杆菌CFP32相比，酵母毕赤酵母中产生的重组结核分枝杆菌CFP32增强了患者血清免疫反应性及其在结核病血清诊断中的潜力。
J Clin Microbiol. 2006 Sep;44(9):3086-93. doi: 10.1128/JCM.02672-05.
8
Disease state differentiation and identification of tuberculosis biomarkers via native antigen array profiling.通过天然抗原阵列分析进行结核病生物标志物的疾病状态区分与鉴定。
Mol Cell Proteomics. 2006 Nov;5(11):2102-13. doi: 10.1074/mcp.M600089-MCP200. Epub 2006 Aug 9.
9
Tuberculosis.结核病
Ann Trop Med Parasitol. 2006 Jul-Sep;100(5-6):415-31. doi: 10.1179/136485906X91477.
10
Mycobacterium tuberculosis malate synthase is a laminin-binding adhesin.结核分枝杆菌苹果酸合酶是一种层粘连蛋白结合黏附素。
Mol Microbiol. 2006 May;60(4):999-1013. doi: 10.1111/j.1365-2958.2006.05151.x.
Zotero 插件