采用液相色谱/质谱（LC/MS）法测定尿液中的对苯二甲酸异丙酰胺。
Determination of terephthalic acid isopropylamide in urine with a liquid chromatography/mass spectrometry (LC/MS) method.
作者信息
Baumann F, Mauz-Körholz C, Clauss D, Borrmann S, Giannis A, Merkel N, Körholz D, Preiss R
机构信息
Institute of Clinical Pharmacology, University of Leipzig, Leipzig, Germany.
出版信息
J Clin Lab Anal. 2008;22(1):21-8. doi: 10.1002/jcla.20213.
Abstract
A sensitive and simple liquid chromatography/mass spectrometry (LC/MS) method was developed for the determination of terephthalic acid isopropylamide, the final metabolite of procarbazine in human urine. A solid-phase extraction with C(18) cartridges was used followed by LC/MS with a single mass spectrometer (SSQ 7000 from Finnigan). Terephthalic acid isobutylamide was the internal standard. The quantification limit was 30 ng/mL in urine (6 x noise). This assay was applied for drug monitoring of terephthalic acid isopropylamide in urine after oral administration of procarbazine in children and adolescents with Hodgkin lymphomas.
摘要
建立了一种灵敏且简便的液相色谱/质谱（LC/MS）方法，用于测定人尿中丙卡巴肼的最终代谢产物对苯二甲酸异丙酰胺。采用C(18)柱进行固相萃取，随后使用配备单台质谱仪（Finnigan公司的SSQ 7000）的LC/MS。对苯二甲酸异丁酰胺为内标。尿样中的定量限为30 ng/mL（6倍噪声）。该方法用于监测患有霍奇金淋巴瘤的儿童和青少年口服丙卡巴肼后尿中对苯二甲酸异丙酰胺的药物浓度。
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