Cho Judy H
Inflammatory Bowel Disease Center, Yale University, 300 Cedar Street, New Haven, CT 06519, USA.
World J Gastroenterol. 2008 Jan 21;14(3):338-47. doi: 10.3748/wjg.14.338.
Genome-wide association studies have firmly established that many genomic loci contribute to inflammatory bowel disease, especially in Crohn's disease. These studies have newly-established the importance of the interleukin 23 and autophagy pathways in disease pathogenesis. Future challenges include: (1) the establishment of precisely causal alleles, (2) definition of altered functional outcomes of associated and causal alleles and (3) integration of genetic findings with environmental factors.
全基因组关联研究已确凿证实，许多基因组位点与炎症性肠病相关，尤其是在克罗恩病中。这些研究重新确立了白细胞介素23和自噬途径在疾病发病机制中的重要性。未来的挑战包括：（1）确定确切的致病等位基因；（2）明确相关和致病等位基因功能改变的结果；（3）将遗传研究结果与环境因素相结合。
