一例原发性皮肤老年EB病毒相关弥漫性大B细胞淋巴瘤。

A case of primary cutaneous senile EBV-related diffuse large B-cell lymphoma.

作者信息

Martin Blanca, Whittaker Sean, Morris Stephan, Robson Alistair

机构信息

Department of Dermatopathology and Skin Tumour Unit, St. John's Institute of Dermatology, London, UK.

出版信息

Am J Dermatopathol. 2010 Apr;32(2):190-3. doi: 10.1097/DAD.0b013e3181ba9e4f.

DOI:10.1097/DAD.0b013e3181ba9e4f

PMID:20068428

Abstract

Epstein-Barr virus is known to be associated with the development of lymphomas in immunosuppressed patients. Recently, age-related immune impairment was recognized as a predisposing factor in the development of Epstein-Barr virus-driven lymphoproliferative processes in elderly patients. We describe the case of an otherwise healthy 84-year-old lady who developed a solitary primary cutaneous diffuse B-cell lymphoma on her leg in which the majority of the malignant cells had Epstein barr early RNA (EBER) and late membrane protein-1 expression, with in situ hybridization and immunohistochemistry, respectively.

摘要

已知爱泼斯坦-巴尔病毒与免疫抑制患者淋巴瘤的发生有关。最近，年龄相关的免疫损害被认为是老年患者发生爱泼斯坦-巴尔病毒驱动的淋巴增殖性病变的一个易感因素。我们描述了一例84岁健康女性的病例，她的腿部出现了一个孤立的原发性皮肤弥漫性B细胞淋巴瘤，通过原位杂交和免疫组化分别检测到大多数恶性细胞有爱泼斯坦-巴尔早期RNA（EBER）和晚期膜蛋白-1表达。