维生素D3类似物的临床效果不会因随后的紫外线照射而失活。
Clinical effect of vitamin D3 analogues is not inactivated by subsequent UV exposure.
作者信息
Adachi Yuka, Uchida Naoko, Matsuo Tomoo, Horio Takeshi
机构信息
Department of Dermatology, Kanssai Medical University, Osaka, Japan.
出版信息
Photodermatol Photoimmunol Photomed. 2008 Feb;24(1):16-8. doi: 10.1111/j.1600-0781.2008.00327.x.
BACKGROUND
Combining phototherapy with topical vitamin D3 analogues is a useful therapy for the treatment of psoriasis by reducing the cumulative UV dose required for clearance of lesions. Experimental investigations demonstrated that calcipotriol is degraded by UV radiation, and suggested that calcipotriol should be applied after phototherapy but not immediately before.
METHODS
Calcipotriol or maxacalcitol ointment was topically applied to psoriatic plaques of six patients immediately before or after phototherapy on the right or left side of the body, respectively.
RESULTS
Topical application of vitamin D3 analogues either before or after irradiation by psoralen and UVA radiation (PUVA) or narrow-band (NB)-UVB showed exactly similar effects in all patients.
CONCLUSION
Therapeutic effects of vitamin D3 analogues are not clinically inactivated by subsequent irradiation with PUVA or NB-UVB phototherapy.
背景
将光疗与外用维生素D3类似物相结合是一种治疗银屑病的有效方法，可减少清除皮损所需的累积紫外线剂量。实验研究表明，卡泊三醇会被紫外线辐射降解，并提示卡泊三醇应在光疗后应用，而不是在光疗前立即应用。
方法
分别在六名患者身体右侧或左侧进行光疗之前或之后，将卡泊三醇或马沙骨化醇软膏局部应用于银屑病斑块。
结果
在所有患者中，在补骨脂素和紫外线A辐射（PUVA）或窄谱（NB）-UVB照射之前或之后局部应用维生素D3类似物均显示出完全相似的效果。
结论
维生素D3类似物的治疗效果不会因随后的PUVA或NB-UVB光疗照射而在临床上失活。
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