Miyoshi Jun, Takai Yoshimi
Department of Molecular Biology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
Biochim Biophys Acta. 2008 Mar;1778(3):670-91. doi: 10.1016/j.bbamem.2007.12.014. Epub 2007 Dec 23.
Actin dynamics play multiple roles in promoting cell movement, changing cell shapes, and establishing intercellular adhesion. Cell contact events are involved in tissue morphogenesis, immune responses, and cancer cell invasion. In epithelial cells, cell-cell contacts mature to form apical junctions with which the actin cytoskeleton physically associates. Living cell imaging shows, however, that the apical junctional complex is less dynamically regulated than the actin cytoskeleton, indicating that their interaction does not remain stable. Given that several cell adhesion modules are clustered at apical junctions, the sum of weak or transient interactions may create linkages that can be strong yet easily remodeled. Here we describe how subcellular protein interactions are coordinated to induce changes in actin organization and dynamics, in response to the status of apical junctions.
肌动蛋白动力学在促进细胞运动、改变细胞形状和建立细胞间黏附中发挥多种作用。细胞接触事件参与组织形态发生、免疫反应和癌细胞侵袭。在上皮细胞中，细胞间接触成熟形成顶端连接，肌动蛋白细胞骨架与之物理结合。然而，活细胞成像显示，顶端连接复合体的动态调节比肌动蛋白细胞骨架少，这表明它们的相互作用并不稳定。鉴于几个细胞黏附模块聚集在顶端连接处，弱或短暂相互作用的总和可能形成既牢固又易于重塑的连接。在这里，我们描述了亚细胞蛋白相互作用是如何协调的，以响应顶端连接的状态，诱导肌动蛋白组织和动力学的变化。
