Ciaramelli Elisa
Rotman Research Institute, 3560 Bathurst Street, Toronto, Ontario M6A 2E1, Canada.
Neuropsychologia. 2008;46(7):2099-105. doi: 10.1016/j.neuropsychologia.2007.11.029. Epub 2007 Dec 8.
A patient with ventromedial prefrontal damage, LG, is described who had a severe difficulty in wayfinding in his home town, despite intact knowledge for landmarks and routes in town. Although able to recall his spatial goals, LG often headed to familiar, "attractor" locations while navigating, losing his way in the process. Both a laboratory and an ecological study showed that spatial navigation improved when the patient was periodically reminded of, or asked to recall, the goal destination along his route. It is suggested that the ventromedial prefrontal cortex is necessary to maintain actively the goal destination in working memory, for use in navigation.
本文描述了一位患有腹内侧前额叶损伤的患者LG，尽管他对家乡的地标和路线了如指掌，但在寻找回家的路时却遇到了严重困难。虽然LG能够回忆起他的空间目标，但在导航时他经常会前往熟悉的“吸引点”位置，在此过程中迷失方向。一项实验室研究和一项生态学研究均表明，当患者被定期提醒或被要求回忆沿途的目标目的地时，其空间导航能力会有所改善。研究表明，腹内侧前额叶皮质对于在工作记忆中积极维持目标目的地以用于导航是必要的。
