A goal pointer for a cognitive map in the orbitofrontal cortex.

Knowing where you are and where you go is a prerequisite for planning a goal-directed journey. The discovery of spatially tuned neurons in the hippocampus and parahippocampal cortices provides a mechanism by which the brain pinpoints an animal's own position in an environment. By contrast, how the brain encodes a remote navigational goal remained largely obscure until recently. In this review, we discuss algorithmic challenges and requirements for the brain to form a representation of a remote navigational goal at which an animal is not present. We then highlight a line of evidence that neurons in the orbitofrontal cortex (OFC) represent a goal location persistently while an animal navigates to this destination. Finally, we propose a new perspective of navigation research opened by this recently reported brain's goal map.