Int J Cardiol. 2009 Apr 17;133(3):399-401. doi: 10.1016/j.ijcard.2007.11.068. Epub 2008 Jan 16.
DNA demethylation agent 5-azacytidine has been widely described in literature as an effective chemical stimulus used to promote cardiomyogenic differentiation in various cell types, ranging from embryonic stem cells, P19 cells, bone marrow-derived mesenchymal stem cells, and recently to adipose-derived stem cells. The purpose of this study was to examine the effects of 5-azacytidine on human adipose precursor cell differentiation along the cardiomyogenic lineage.
DNA 去甲基化剂 5-氮杂胞苷在文献中被广泛描述为一种有效的化学刺激物,可用于促进各种细胞类型的心肌生成分化,包括胚胎干细胞、P19 细胞、骨髓间充质干细胞,最近还包括脂肪来源干细胞。本研究旨在探讨 5-氮杂胞苷对人脂肪前体细胞向心肌生成谱系分化的影响。