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人脂肪前体细胞的成心肌分化潜能。

Cardiomyogenic differentiation potential of human adipose precursor cells.

出版信息

Int J Cardiol. 2009 Apr 17;133(3):399-401. doi: 10.1016/j.ijcard.2007.11.068. Epub 2008 Jan 16.

DOI:10.1016/j.ijcard.2007.11.068
PMID:18201779
Abstract

DNA demethylation agent 5-azacytidine has been widely described in literature as an effective chemical stimulus used to promote cardiomyogenic differentiation in various cell types, ranging from embryonic stem cells, P19 cells, bone marrow-derived mesenchymal stem cells, and recently to adipose-derived stem cells. The purpose of this study was to examine the effects of 5-azacytidine on human adipose precursor cell differentiation along the cardiomyogenic lineage.

摘要

DNA 去甲基化剂 5-氮杂胞苷在文献中被广泛描述为一种有效的化学刺激物,可用于促进各种细胞类型的心肌生成分化,包括胚胎干细胞、P19 细胞、骨髓间充质干细胞,最近还包括脂肪来源干细胞。本研究旨在探讨 5-氮杂胞苷对人脂肪前体细胞向心肌生成谱系分化的影响。

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1
Cardiomyogenic differentiation potential of human adipose precursor cells.人脂肪前体细胞的成心肌分化潜能。
Int J Cardiol. 2009 Apr 17;133(3):399-401. doi: 10.1016/j.ijcard.2007.11.068. Epub 2008 Jan 16.
2
Exposure to cardiomyogenic stimuli fails to transdifferentiate human umbilical cord blood-derived mesenchymal stem cells.暴露于心肌生成刺激未能使人类脐带血源性间充质干细胞转分化。
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In vitro cardiomyogenic differentiation of adult human bone marrow mesenchymal stem cells. The role of 5-azacytidine.成人骨髓间充质干细胞的体外心肌分化。5-氮杂胞苷的作用。
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5-Azacytidine-treated human mesenchymal stem/progenitor cells derived from umbilical cord, cord blood and bone marrow do not generate cardiomyocytes in vitro at high frequencies.经5-氮杂胞苷处理的源自脐带、脐血和骨髓的人间充质干/祖细胞在体外并不能高频产生心肌细胞。
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Effect of 5-azacytidine: evidence for alteration of the multipotent ability of mesenchymal stem cells.5-氮杂胞苷的作用:对间充质干细胞多能性改变的证据。
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Cardiomyogenic potential of human adult bone marrow mesenchymal stem cells in vitro.成人骨髓间充质干细胞体外的心肌生成潜能
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Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine.
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Differentiation of adipose stem cells.脂肪干细胞的分化
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引用本文的文献

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Comparison of Sources and Methods for the Isolation of Equine Adipose Tissue-Derived Stromal/Stem Cells and Preliminary Results on Their Reaction to Incubation with 5-Azacytidine.马脂肪组织来源的基质/干细胞分离的来源和方法比较及其与5-氮杂胞苷孵育反应的初步结果
Animals (Basel). 2022 Aug 11;12(16):2049. doi: 10.3390/ani12162049.
2
A Comparative Study of the Effect of Anatomical Site on Multiple Differentiation of Adipose-Derived Stem Cells in Rats.大鼠脂肪干细胞在解剖部位上的多向分化效果比较研究。
Cells. 2021 Sep 18;10(9):2469. doi: 10.3390/cells10092469.
3
Adipose tissue-derived stem cells: a comparative review on isolation, culture, and differentiation methods.
脂肪组织来源的干细胞:分离、培养及分化方法的比较综述
Cell Tissue Bank. 2022 Mar;23(1):1-16. doi: 10.1007/s10561-021-09905-z. Epub 2021 Feb 22.
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Effects of hydroxyapatite-coated nonwoven polyethylene/polypropylene fabric on non-mesodermal lineage-specific differentiation of human adipose-derived stem cells.羟基磷灰石涂层非织造聚乙烯/聚丙烯织物对人脂肪来源干细胞非中胚层谱系特异性分化的影响
BMC Res Notes. 2020 Oct 7;13(1):471. doi: 10.1186/s13104-020-05315-8.
5
Mesenchymal stem cell mediates cardiac repair through autocrine, paracrine and endocrine axes.间充质干细胞通过自分泌、旁分泌和内分泌轴介导心脏修复。
J Transl Med. 2020 Sep 1;18(1):336. doi: 10.1186/s12967-020-02504-8.
6
Differentiation of brown adipose-derived stem cells into cardiomyocyte-like cells is regulated by a combination of low 5-azacytidine concentration and bone morphogenetic protein 4.棕色脂肪来源干细胞向心肌样细胞的分化受低浓度5-氮杂胞苷和骨形态发生蛋白4共同调控。
Int J Clin Exp Pathol. 2018 Nov 1;11(11):5514-5524. eCollection 2018.
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Differentiation of human adipose-derived stem cells into cardiomyocyte-like cells in fibrin scaffold by a histone deacetylase inhibitor.组蛋白去乙酰化酶抑制剂在纤维蛋白支架上诱导人脂肪干细胞向心肌样细胞分化。
Biomed Eng Online. 2017 Nov 23;16(1):134. doi: 10.1186/s12938-017-0423-y.
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J Intensive Care Soc. 2015 Nov;16(4):320-329. doi: 10.1177/1751143715586420. Epub 2015 May 21.
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Mol Cell Biochem. 2017 Sep;433(1-2):61-77. doi: 10.1007/s11010-017-3016-y. Epub 2017 Apr 5.